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EC number: 231-901-9 | CAS number: 7778-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Testing was performed for 2 years in rats and dogs with sodium arsenate.
In rats, marked enlargement of the common bile duct was observed at 250 and 400 ppm and these levels also caused weight depression and decreased survival. Body weight was slightly reduced in both sexes at 125 ppm. The NOAEL in rat for sodium arsenate is then 62.5 ppm equivalent to 3.1 mg/kg bw/day.
In dogs, high dose groups showed no treatment-related systemic effects except for weight depression and mild anemia. Only microscopic finding related to treatment was the presence of granular, brownish, iron-positive, nonbirefringent pigment in the liver macrophages in all dogs at high dose groups but was seen only randomly below this level and was noted in one control animal. The NOAEL in dog for sodium arsenate is then 50 ppm equivalent to 1.25 mg/kg bw/day.
For the derivation of a key value for chemichal safety assessment of arsenic acid, carcinogenicity appears as the critical end-point with lowest NOAEL and will therefore be used to derive the DNEL.
Key value for chemical safety assessment
Additional information
In a 2 year study, sodium arsenate was administered through feed to groups of 50 weanling Osborne-Mendel rats/sex/dose at 400, 250, 125, 62.5 and 31.25 ppm. Main finding were a slight increase of leukocyte count in the females at the highest dosage throughout the experiment and in the males for the first year. No distinct differences in ratio of organ weight to body weight were noted. Marked enlargement of the common bile duct was observed at 250 and 400 ppm and these levels also caused weight depression and decreased survival. At 250 ppm, survival was slightly reduced, enlargement of the common bile duct (less pronounced) and reduced weight, particularly in females was observed. At 125, 62.5 and 31.25 ppm, arsenate did not cause common bile duct enlargement and did not affect survival. Body weight was slightly reduced in both sexes at 125 ppm. No carcinogenic effect could be detected. Histopathologically, enlarged common bile ducts showed hyperplasia of the glandular elements, focal necrosis and fibrosis. The NOAEL in rat for sodium arsenate is then 62.5 ppm equivalent to 3.1 mg/kg bw/day.
In the same study, sodium arsenate was administered through feed to groups of 6 Beagle dogs/sex/dose at 125, 50, 25 and 5 ppm. Only one of six dogs on the high level of arsenate died, and this one dog lost much weight. High dose groups showed no treatment-related systemic effects except for weight depression and mild anemia. No gross pathology was reported except for weight loss at the high level and traumatic brain hemorrhage in one dog. Only microscopic finding related to treatment was the presence of granular, brownish, iron-positive, nonbirefringent pigment in the liver macrophages in all dogs at high dose groups but was seen only randomly below this level and was noted in one control animal. The NOAEL in dog for sodium arsenate is then 50 ppm equivalent to 1.25 mg/kg bw/day.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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