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Diss Factsheets
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EC number: 231-901-9 | CAS number: 7778-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
- Oral: LD50 (male/female) for arsenic acid (75% w/w) = 149.6 (114.4-195.5) mg/kg bw for mice (OECD TG 401)
- Dermal: LD50 (male/female) for arsenic acid = 2000 (1583-2417) mg/kg bw for rabbits (OECD TG 402)
- lnhalation: LC50 (male/female) for arsenic acid (aerosol) = 1.040 (0.512-1.567) mg/L for mice (OECD TG 403)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 149.6 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 1 040 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
In an acute oral toxicity study performed similarly to OECD guideline 401 and in compliance with GLP, groups of Crl:CD-1 (ICR) BR mice (5/sex/dose) were given a single oral dose of arsenic acid (75% w/w) at 75, 100 and 200 mg/kg bw. The acute oral LD50 for males and females were determined to be 141.4 (98.8-202.3) and 160.4 (107.1-240.3) mg/kg bw, respectively. The combined oral LD50 was calculated to be 149.6 (114.4-195.5) mg/kg bw.
In an acute dermal toxicity study performed similarly to OECD guideline 402 and in compliance with GLP, groups of New Zealand White rabbits (5/sex/dose) received a single dermal dose of Desiccant L-10 (arsenic acid) at 200, 400, 800, 1600 and 3200 mg/kg bw on clipped area of the trunk representing at least 10% of the total body surface area. Dermal reactions noted in several animals were necrosis followed by eschar formation and exfoliation. The acute dermal LD50 for males and females were determined to be 1750 (944-2556) and 2300 mg/kg bw, respectively. The combined dermal LD50 was calculated to be 2000 (1583-2417) mg/kg bw.
In an acute inhalation toxicity study performed similarly to OECD guideline 403 and in compliance with GLP, groups (5/sex) of CD-1 mice were exposed (whole-body) to aerosol atmosphere of arsenic acid at concentrations of 0.57, 1.01 and 2.41 mg/L (analytical TWA) or 24.9, 49.1 and 206.7 mg/L (nominal) for 4 hours. The acute inhalation LC50 for males and females were determined to be 0.794 (0.548-1.149) and 1.153 (0.410-1.897) mg/L (analytical), respectively. The acute inhalation combined LC50 was 1.040 (0.512-1.567) mg/L (analytical).
Justification for classification or non-classification
- The oral LD50 for arsenic acid (75% w/w) is in the range of 50-200 mg/kg bw in mice therefore it is classified as ‘R25 Toxic if swallowed’ according to the Annex VI to the Directive 67/548/EEC and ‘category 3’ according to the CLP Regulation (EC) N° (1272-2008).
- The dermal LD50 for arsenic acid was calculated to be 2000 (1583-2417) mg/kg bw in rabbits therefore it is classified as ‘R21 Harmful in contact with skin’ according to the Annex VI to the Directive 67/548/EEC and ‘Category 4’ according to the CLP Regulation (EC) N° (1272-2008).
- The inhalation LC50 for arsenic acid (aerosol) is 1 mg/L in mice therefore it is classified as ‘R23 Toxic by inhalation’ according to the Annex VI to the Directive 67/548/EEC and ‘Category 3’ in the CLP Regulation (EC) N° (1272-2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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