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Diss Factsheets
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EC number: 231-901-9 | CAS number: 7778-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From February 04 to March 06, 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted similarly to OECD guideline 404 with only minor deviations: observation not done immediately following removal of the test substance, no data on purity and bodyweights not followed.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- yes
- Remarks:
- observation not done immediately following removal of the test substance. No data on purity and bodyweights not followed
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- observation not done immediately following removal of the test substance. No data on purity and bodyweights not followed
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- Arsenic acid
- EC Number:
- 231-901-9
- EC Name:
- Arsenic acid
- Cas Number:
- 7778-39-4
- Molecular formula:
- H3AsO4
- IUPAC Name:
- arsoric acid
- Details on test material:
- - Name of test material (as cited in study report): Desiccant L-10
- Source: Pennwalt Corporation, USA
- Physical state: Light blue, clear liquid
- Date of receipt: January 4, 1985
- Lot/batch No.: 8158
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton-Dutchland, Inc., Denver, USA
- Age at study initiation: Young adults
- Housing: Individually housed in suspended, stainless steel cages
- Diet (e.g. ad libitum): Lab Rabbit Chow HF (Purina #5326), ad libitum
- Water (e.g. ad libitum): Municipal water supply (Elizabethtown Water Co.), ad libitum
- Acclimation period: 29 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 60-70 °F
- Humidity (%): 30-70%
- Photoperiod (hours dark / hours light): 12 hours dark / 12 hours light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24 hours
- Number of animals:
- Six (3 males, 3 females)
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal surface (scapular to lumbar region)
- Type of wrap if used: Test material (0.5 mL) was applied beneath a surgical gauze (1” X 1”), placed directly on the test sites and then secured in position with tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Test sites were not washed but wiped free of excess test material
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize scoring system (1959)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 30 min.
- Score:
- 3.16
- Max. score:
- 4
- Reversibility:
- other: animals died within 24 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 30 min.
- Score:
- 3.16
- Max. score:
- 4
- Reversibility:
- other: all animals died within 24 hours
- Irritant / corrosive response data:
- - Three animals exhibited tissue destruction (necrosis) at the application site at 4.5 hours post-exposure (30 min. after removal of wrappings); the other three animals exhibited moderate to severe erythema and edema.
- Other effects:
- - Mortality and clinical signs of toxicity: All six animals were found dead within 24 hours after dosing. No unusual antemortem signs were noted.
- Necropsy: Red fluid in the gall bladders of 4/6 animals and clear fluid in the abdominal cavity of one animal; other observations appeared to represent postmortem autolytic changes (discoloration), antemortem stress (brown foci in stomach walls, testes in body cavity) or normal physiological changes
Any other information on results incl. tables
Table 1: Individual dermal irritation score at 4.5 hours post-exposure
|
Animal No. 1 |
Animal No. 2 |
Animal No. 3 |
Animal No. 4 |
Animal No. 5 |
Animal No. 6 |
Erythema |
4 |
4 |
3 |
2 |
2 |
4 |
Edema |
3 |
3 |
4 |
3 |
4 |
2 |
Applicant's summary and conclusion
- Interpretation of results:
- Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, arsenic acid is classified as corrosive to the skin, ‘R34 Causes burns’ according to the criteria of Annex VI of the Directive 67/548/EEC and ‘ Category 1: Corrosive 1C’ in CLP Regulation (EC) No. 1272/2008.
- Executive summary:
In a primary dermal irritation study performed similarly to OECD guideline 404 and in compliance with GLP, six (3/sex) New-Zealand White rabbits were dermally exposed to 0.5 mL of undiluted Desiccant L-10 (arsenic acid), under a semi-occlusive bandage for 4 hours to clipped skin of the dorsal surface (scapular to lumbar region). Animals were then observed for 24 hours. Irritation was scored by the method of Draize (1959).
Three of the six animals exhibited tissue destruction (necrosis) at the application site at 4.5 hours post-exposure (30 min. after removal of wrappings); the other three animals exhibited moderate to severe erythema and edema. All six animals were found dead within 24 hours after dosing. In this study, arsenic acid was found to be corrosive when applied topically to the rabbit.
Under the test conditions, arsenic acid is classified as corrosive to the skin, ‘R34 Causes burns’ according to the criteria of Annex VI of the Directive 67/548/EEC and ‘ Category 1: Corrosive 1C’ in CLP Regulation (EC) No. 1272/2008.
This study is acceptable and satisfies the guideline requirement for an acute dermal irritation study (OECD 404).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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