Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-901-9 | CAS number: 7778-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Endpoint summary
Administrative data
Description of key information
Additional information
Arsenic acid (AA) is an inorganic compound of arsenic (As). There are no proprietary studies investigating the bioaccumulation of AA either in aquatic/sediment species or in terrestrial species. However, several studies have been performed to investigate the bioaccumulation of As compounds in various organisms. This section aims to give an overview of the available data on bioaccumulation of As and is based on few review documents:
-United States Environmental Protection Agency (US EPA), 2004, Technical Summary of Information Available on the Bioaccumulation of Arsenic in Aquatic Organisms, Office of Science and Technology, Office of Water, EPA-822-R-03-032.
-World Health Organization (WHO), 2001, Arsenic and arsenic compounds, Environmental Health Criteria 224.
-Agency for Toxic Substances and Disease Registry U.S. Public Health Service (2007). Toxicological profile for arsenic. 559p.
Arsenic bioaccumulation depends on various factors such as the compartment considered (e.g. freshwater, seawater), the exposure concentration and the route of exposure. The range of BCF values for aquatic organisms suggest that As is accumulated to a greater or a lesser degree with Fish BCF being generally below 2000. Biomagnification of As does not appear to be significant.
Microorganisms
Phytoplankton takes up arsenate readily and incorporates a small proportion into the cell. Most of the arsenate is reduced, methylated and released in the surrounding media. Phytoplankton readily incorporated dissolved arsenic, with average As residues increasing from 5.7 to 17.7 mg/kg (dw) when cultured for 48-96 h at 25 µg As(V)/L as As.
The accumulation of trivalent and pentavalent As by the green alga, Chlorella vulgaris, isolated from an As contaminated environment has been examined. Bioconcentration factors (BCFs) ranged from 1.4 to 330 with exposure concentrations of 0 to 10,000 mg/L.
Other BCF data for microorganisms are reported here under as cited in the review documents:
Estuarine phytoplankton, Thalassiosira pseudomonas, Skeletonema costatum and Dunaliella tertiolecta (origin of organisms not stated in the review), BCF range: 1,462–3,688, exposure concentration 25 µg As(+5)/L, exposure duration: 48h.
Algae (no more details in the review), BCF : 370 (sand microcosms), BCF: 4300 (lake mud microcosm), exposure concentration: 50 µgAs(+5)/L, exposure duration 5 wk.
Macroalgae
Few data are available indicating that As can be bioaccumulated by macroalgae. One BCF data for macroalgae is reported here under as cited in the review documents:
Aquatic plant, Hydrilla verticillata, BCF range (steady-state) 110–190, exposure concentration: 0.4-0.8 mg As(+5)/L, exposure duration: 16 d.
Aquatic invertebrates
Bioaccumulation of As has been studied in several aquatic invertebrate species and are reported in the review documents (WHO Review). Some data are reported here under:
Polychaete, Tharyx marioni, BCF(1) = 4.5 for exposure concentration of 10 mg As(+5)/L, BCF(2) = 111.6 for exposure concentration of 0.01 mg/L, exposure duration: 7 d.
Polychaete, Caulleria caputescocis, BCF = 15.9, exposure concentration: 0.01 mg/L.
Crustacean, Shrimps, BCF < 10, exposure concentration: 20-100 µgAs(+5)/L, exposure duration: 14 d.
Crustacean, Grass shrimp (Palaemonetes pugio), BCF ND (no bioaccumulation of arsenate), exposure concentration: 25 µgAs(+5)/L.
Fish
A large dataset of fish bioaccumulation studies on As has been reviewed by US EPA (2003). The BCF values in this dataset ranged from 0.048 to 1,390.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)