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Diss Factsheets
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EC number: 202-849-4 | CAS number: 100-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 949
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VI
- Author:
- Smyth, Jr. H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C. and Striegel, J.A.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 23:95-107
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guideline available
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Ethylbenzene
- EC Number:
- 202-849-4
- EC Name:
- Ethylbenzene
- Cas Number:
- 100-41-4
- Molecular formula:
- C8H10
- IUPAC Name:
- ethylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Ethylbenzene
- Physical state: liquid
- Analytical purity: not specified in the report
- Impurities (identity and concentrations): not specified in the report
- Composition of test material, percentage of components: not specified in the report
- Isomers composition: not specified in the report
- Purity test date: not specified in the report
- Lot/batch No.: 719
- Expiration date of the lot/batch: not specified in the report
- Stability under test conditions: not specified in the report
- Storage condition of test material: not specified in the report
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not specified in the report
- Age at study initiation: not specified in the report
- Weight at study initiation: 2-3 kg
- Fasting period before study: non-fasted
- Housing: not specified in the report
- Diet (e.g. ad libitum): not specified in the report
- Water (e.g. ad libitum): not specified in the report
- Acclimation period: not specified in the report
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified in the report
- Humidity (%): not specified in the report
- Air changes (per hr): not specified in the report
- Photoperiod (hrs dark / hrs light): not specified in the report
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The fur was removed from the entire trunk by clipping and the dose was retained beneath an impervious plastic film 24 hour application. Animals were observed for an additional 13 days.
- Duration of exposure:
- 24 hours
- Doses:
- 20 ml/kg, 15.8 ml/kg and 12.6 ml/kg
- No. of animals per sex per dose:
- 5 male rabbits/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified in the report
- Necropsy of survivors performed: not specified in the report - Statistics:
- The most probable LD50 value was estimated by the method of Thompson using the tables of Weil.
Results and discussion
- Preliminary study:
- Not specified
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 17.8 mL/kg bw
- Remarks on result:
- other: R.F. LD50 (calculated 15.4326 g/kg, based on specific gravity of 0.867)
- Mortality:
- 20 ml/kg - 3/5 rabbits
15.8 ml/kg - 2/5 rabbits
12.6 ml/kg - 1/5 rabbits - Clinical signs:
- other: not specified in the report
- Gross pathology:
- not specified in the report
- Other findings:
- not specified in the report
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The estimated R.F. LD50 was 17.8 ml/kg (calculated 15.4 g/kg, based on specific gravity of 0.867) under the study conditions.
- Executive summary:
Ethylbenzene was tested for dermal toxicity in rabbits (5 male rabbits/dose) at doses of 20.0, 15.8 and 12.6 ml/kg and killed 3 out 5 rabbits at 20 ml/kg, 2 of 5 at 15.8 ml/kg and 1 of 5 at 12.6 ml/kg. Based on the results obtained, the estimated R.F. LD50 was 17.8 ml/kg (calculated 15.4 g/kg, based on specific gravity of 0.867) under the study conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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