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Diss Factsheets
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EC number: 202-849-4 | CAS number: 100-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: publication
- Adequacy of study:
- other information
- Study period:
- 1975
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Report to RIFM
- Author:
- Kligman, A.M.
- Year:
- 1 975
- Bibliographic source:
- Food Cosmet. Toxicol. 13:803-804
- Reference Type:
- secondary source
- Title:
- Fragrance raw material monographs. Ethylbenzene
- Author:
- Opdyke, D.L.J.
- Year:
- 1 975
- Bibliographic source:
- Food Cosmet. Toxicol 13:803-804
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Maximization test as cited in Kligman (1966) and Kligman and Epstein (1975).
Ethylbenzene was applied under occlusion to the same site on the volar forearms of all subjects for 5 alternate day 48 hr periods. The patch site was pre-treated for 24 hrs with 5% aqueous solution of sodium lauryl sulfate under occlusion. The challenge sites were read on removal of the patch and 24 hrs later. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethylbenzene
- EC Number:
- 202-849-4
- EC Name:
- Ethylbenzene
- Cas Number:
- 100-41-4
- Molecular formula:
- C8H10
- IUPAC Name:
- ethylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Ethylbenzene
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- human volunteers
- Clinical history:
- No data
- Controls:
- No data
- Route of administration:
- dermal
- Details on study design:
- Maximization test as cited in Kligman (1966) and Kligman and Epstein (1975).
Ethylbenzene was applied under occlusion to the same site on the volar forearms of all subjects for 5 alternate day 48 hr periods. The patch site was pre-treated for 24 hrs with 5% aqueous solution of sodium lauryl sulfate under occlusion. The challenge sites were read on removal of the patch and 24 hrs later.
Results and discussion
- Results of examinations:
- Not sensitizing.
No. with positive reactions: 48 and 72 hr readings: 0 out of 25 (test group); dose: 10%
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Based on the results of the study ethylbenzene was not sensitising to human.
- Executive summary:
This maximization test was carried out with ethylbenzene (10% in petrolatum) in 25 human volunteers. There were no sensitisation reactions. No further details are available as this is a reference to unpublished data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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