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Diss Factsheets
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EC number: 202-849-4 | CAS number: 100-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: publication
- Adequacy of study:
- key study
- Study period:
- 1930
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: While the observation are considered valid the usefulness of this information is diminished by lack of information on purity of the test sample which was described as a commercial product. There was also no analysis for the test atmosphere.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute response of guinea pigs to vapours of some new commercial organic compounds II Ethylbenzene
- Author:
- Yant, W. P.; Schrenk, H.H.; Waite, C.P.; Patty, F.A.
- Year:
- 1 930
- Bibliographic source:
- Publ. Health Res. 45:1241-1250
Materials and methods
- Type of study / information:
- Sensory irritation
- Endpoint addressed:
- eye irritation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethylbenzene
- EC Number:
- 202-849-4
- EC Name:
- Ethylbenzene
- Cas Number:
- 100-41-4
- Molecular formula:
- C8H10
- IUPAC Name:
- ethylbenzene
- Details on test material:
- No data
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- No data
- Exposure assessment:
- not specified
- Details on exposure:
- No data
Results and discussion
- Results:
- Three observers upon entering a 0.5% (5000 ppm) mixture of ethylbenzene with air found the atmosphere intoler-able, being extremely irritating to the eyes, nose and throat. It was the opinion of the men exposed to the vapours of ethylbenzene that a 0.2% (2000 ppm) concentration of vapour would give ample warning and would not be tolerated; and that 0.5% (5000 ppm) would have sufficient irritating properties to render working in this atmosphere impossible.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Three observers upon entering a 0.5% (5000 ppm) mixture of ethylbenzene with air found the atmosphere intolerable, being extremely irritating to the eyes, nose and throat. It was the opinion of the men exposed to the vapours of ethylbenzene that a 0.2% (2000 ppm) concentration of vapour would give ample warning and would not be tolerated; and that 0.5% (5000 ppm) would have sufficient irritating properties to render working in this atmosphere impossible.
- Executive summary:
Ethylbenzene (no data on purity described as a commercial product) was tested for sensory irritation in humans. Six men breathing 0.1% (1000 ppm) vapour in air found the atmosphere very irritating to the eyes, producing a sensation of smarting and burning, accompanied by profuse lacrimation. This irritation gradually decreased on continued exposure until, after a minute or two, it was scarcely notable. Two men upon leaving and returning to the chamber noticed no eye irritation. It was the opinion of the observers that this atmosphere could be tolerated after the first few minutes. The same six observers found 0.2% (2000 ppm) vapour almost intolerable on first entering the chamber, although it became less irritating upon continued exposure. One observer stayed five minutes and found that the irritation to the eyes and throat gradually disappeared, but vertigo developed. Exposure to 0.2% (2000 ppm) was accompanied by throat irritation and a feeling of constriction in the chest. Four observers exposed six minutes while a concentration of 0.2% (2000 ppm) was "built up" noticed a moderate nasal irritation and a moderate to strong eye irritation. All complained about dizziness upon leaving the atmosphere. Three observers upon entering a 0.5% (5000 ppm) mixture of ethylbenzene with air found the atmosphere intoler-able, being extremely irritating to the eyes, nose and throat. It was the opinion of the men exposed to the vapours of ethylbenzene that a 0.2% (2000 ppm) concentration of vapour would give ample warning and would not be tolerated; and that 0.5% (5000 ppm) would have sufficient irritating properties to render working in this atmosphere impossible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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