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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
From a peer reviewed publication.

Data source

Reference
Reference Type:
publication
Title:
Toxicology of Cationic Surfactants.
Author:
Cutler RA and Drobeck HP
Year:
1970
Bibliographic source:
Cationic Surfactants. Vol. 4 (Chap. 15). Jungermann E (Ed.) Marcel Dekker, Inc., New York.

Materials and methods

Principles of method if other than guideline:
Method: other: Draize test for TIC determination
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Didecyldimethylammonium chloride
EC Number:
230-525-2
EC Name:
Didecyldimethylammonium chloride
Cas Number:
7173-51-5
Molecular formula:
C22H48N Cl
IUPAC Name:
didecyldimethylammonium chloride
Test material form:
not specified
Details on test material:
- Didecyldimethylammonium chloride (DDAC)
- EC number: 230-525-2

To the best of knowledge, the sample used is representative to the boundary composition shared and agreed by each registrant

Test animals / tissue source

Species:
rabbit

Test system

Amount / concentration applied:
Concentration: 0.1 % active substance
Amount applied: 0.1 ml
Number of animals or in vitro replicates:
5

Results and discussion

Any other information on results incl. tables

Threshold Irritant Concentration (TIC) for dialkyldimethylammonium chloride (C8-C18) and
Didecyldimethylammonium chloride has been established. The concept of the threshold is introduced to indicate minimum
percentage concentration at which only mild irritation occurs as defined by the Draize scoring method. Thus, by
using a series of graded concentrations of each compound a measurement of this threshold is obtained:

Threshold Irritant Concentration (TIC) determined in the eyeof the rabbit.

Dialkyldimethylammonium chloride (C8-C18):
Conc.  No. of  Max. ave.   Adjective 
(%)     eyes     score     rating
____________________________________
0.063    5       4.4       Mild
0.125    5       7.2       Moderate
0.25     5       22.4      Severe
TIC = 0.063 

Didecyldimethylammonium chloride:
Conc.  No. of  Max. ave.   Adjective 
(%)     eyes     score     rating
_____________________________________
0.063    5       4.4       Mild
0.125    5      10.8       Moderate
0.25     5      20.8       Severe
0.5      5      33.6       Severe
TIC = 0.063

Reference: 
Duprey LP, Hoppe JO, report on Toxicity and Irritatiion Studies on Quaternary Ammonium Compounds, files of Sterling
-Winthrop Research Institute, unpublished, 1967.

Applicant's summary and conclusion

Conclusions:
DDAC is expected to be severely damaging to eyes based on its corrosive nature. Concentrations as low as 0.1 to 0.5% are often irritating to conjunctivae and mucous membranes..
Executive summary:

DDAC is expected to be severely damaging to eyes based on its corrosive nature. Concentrations as low as 0.1 to 0.5% are often irritating to conjunctivae and mucous membranes..