Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2d: Meets national standards with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
- Principles of method if other than guideline:
- Method: other: FDA guideline, likely acc. to Draize Test
- GLP compliance:
- no
Test material
- Reference substance name:
- Silicic acid, aluminum sodium salt
- EC Number:
- 215-684-8
- EC Name:
- Silicic acid, aluminum sodium salt
- Cas Number:
- 1344-00-9
- Details on test material:
TS-Freetext: Sodium aluminium silicate, amorphous, size of particle
aggregates: 3.5-65 um (based on SEM), not further specified Silicic acid, aluminum sodium salt
-Name of test material : Silicic acid, aluminum sodium salt
- CAS mumber: 1344-00-9
- EC number: 215-684-8
- Generic empiricalformula: : nSiO2 • mAl203• xNa20
- Molecular weight : 60.08g/mol (SiO2)
- Substance type:inorganic
- Physical state: solid
-Colour : White
-Odour : Odourless
- Density: 2.1 g/cm3 at 20 °C
- Melting point: 1700 °C
- Boiling point: 1 >>1700 °C: not relevant for normal and intended use
- Solubility in water: 68-79 mg/l at 20 °C
- Tradenames: Sipernat, Alusil ET, Zeolex, Hydrex, Huberfil, Durabrite, Zeocopy, Tixolex, Rhodoxane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Dutch
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- Concentration: 100 % active substance
Amount applied: 100 other: mg - Duration of treatment / exposure:
- 48 h
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Comment: not rinsed
Results and discussion
In vivo
Results
- Irritation parameter:
- other: erythema
- Basis:
- animal #6
- Time point:
- other: 12 h, 24h, 72h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: Only slight erythema (score <1) after 24 h in 4/6 animals, after 48 h 1/6 animals still exhibited some effect.
- Irritant / corrosive response data:
- Only slight erythema (score <1) after 24 h in 4/6 animals, after 48 h 1/6 animals still exhibited some effect. No signs of irritation after 72 h
Any other information on results incl. tables
RS-Freetext:
Only slight erythema (score <1) after 24 h in 4/6 animals,
after 48 h 1/6 animals still exhibited some effect. No signs
of irritation after 72 h.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information No signs of irritation after 72 h. Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Only slight erythema (score <1) after 24 h in 4/6 animals, after 48 h 1/6 animals still exhibited some effect. No signs of irritation after 72 h.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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