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EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
No skin irritation and corrosion reactions were observed with aluminium sulphate treatment up to 233.5 mg/kg bw
Instillation of aluminum sulphate into the eye results in conjunctivitis and purulent ophthalmitis. Aluminum sulphate and coagulants afflict the nervous system, liver and heart. The recommended MAC in the air of workplace for aluminum sulphate, is equal to 0.5 mg/m3.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin damage has been observed in female TF1 Carworth mice, New Zealand rabbits, and Large White pigs following the application of 10% aluminum chloride (0.005–0.1 g Al) or aluminum nitrate (0.006–0.013 g Al) for 5 days; but not from aluminum sulfate, hydroxide, acetate, or chlorhydrate (Lansdown1973). The damage consisted of hyperplasia, microabscess formation, dermal inflammatory cellinfiltration, and occasional ulceration. These results suggest that the development of adverse dermaleffects from exposure to aluminum depends upon its chemical form..
The 10% solutions of aluminium chloride produced a slightly corrosive effect.
In occupational settings, instillation of aluminium sulphate into the eye, have resulted in conjunctivitis and purulent ophthalmitis (Grekhova et al., 1994). Other forms of aluminium relevant to cosmetics (aluminium starch octenylsuccinate) have also been shown to cause mild eye irritation in rabbits, although the authors concluded that this exposure was unlikely to cause irritation in humans (Nair & Yamarik, 2002).
References: Nair B,Yamarik TA; Final report on the safety assessment of aluminum starch octenylsuccinate., Int J Toxicol. 2002;21 Suppl 1:1-7.
Effects on eye irritation: moderately irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Justifiction for eye classification:
Instillation of aluminum sulphate into the eye results in conjunctivitis and purulent ophthalmitis. Aluminum sulphate and coagulants afflict the nervous system, liver and heart. The recommended MAC in the air of workplace for aluminum sulphate, is equal to 0.5 mg/m3.
Classification: Eye Damage 1
H318: Causes serious eye damage.
Based on the hazard assessment of aluminium sulphate in section 2.1 and 2.2.in IUCLID 5.2., available data for the substance and following the “Guidance on Information Requirement and Chemical Safety Assessment R.8. Characterisation of dose [concentration]- response for human health” andaccording to the criteria described in Directive 67/548 and in the CLP Regulation:
Directive 67/548 |
Skin Corrosivity C R35 Causes severe burns R34 Causes burns Skin Irritation Xi R38 Irritating to skin R43 May cause sensitization by skin contact Eye Irritation (Ocular Lesions) Xi R36 Irritating to eyes R41 Risk of serious damage to eyes |
CLP |
Skin Corrosivity H314 Skin Corr 1A Causes severe skin burns and eye damage H314 Skin Corr 1B Causes severe skin burns and eye damage Skin Irritation H315 Skin Irrit. 2 Causes skin irritation H317 Skin Sens. 1 May cause an allergic skin reaction Eye Irritation (Ocular Lesions) Xi H319 Eye Irrit. 2 Causes serious eye irritation H318 Eye Dam. 1 Causes serious eye damage |
It is concluded that the substance aluminium sulphate meet the criteria to be classified for human health hazards for Dermal-local effect:R41 Risk of serious damage to eyes, Eye Damage 1, H318: Causes serious eye damage.
Justification for skin non-classification:
Conclusive but not sufficient for classification
No skin irritation and corrosion reactions were observed with aluminium sulphate treatment up to 233.5 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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