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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Method: Investigations of the accumulation and effect of desulphur Gypsum on the organism, particularly the lungs,following intratracheal application.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- repeated dose toxicity: inhalation
- genetic toxicity
Test material
- Reference substance name:
- Calcium sulfate
- EC Number:
- 231-900-3
- EC Name:
- Calcium sulfate
- Cas Number:
- 7778-18-9
- IUPAC Name:
- calcium sulfate
- Reference substance name:
- calcium sulphate
- IUPAC Name:
- calcium sulphate
- Details on test material:
- - Name of test material: Calcium sulfate
- CAS number :7778-18-9
- EC Number: 231-900-3
- Molecular formula (if other than submission substance): CaSO4
- Molecular weight (if other than submission substance): 136.14 g/mol
- Smiles notation (if other than submission substance): [Ca+2].[O-]S([O-])(=O)=O
-InChl (if other than submission substance):=1/Ca.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
- Structural formula attached as image file (if other than submission substance): see Fig.1
- Substance type:inorganic
- Physical state:solid
- Appearance: white solid
- Density -2.96 g/cm3)
- Melting point-1460 °C
- Solubility in water - 2.1 g/L (20 °C
- Synonyms: Plaster of Paris, Drierite,, Gypsum
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Long-term investigations have been carried out on Wistar rats for up to 18 months.
Administration / exposure
- Route of administration:
- intratracheal
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Long-term investigations have been carried out on Wistar rats for up to 18 months. Changes in lung tissue indicate unspecific bronchiolitis present also in controls. No foreign body accumulation would be observed in lung tissue or in hilus lymph nodes. A diffuse increase in the interstitial connective tissue was not proven. A cytotoxicological effect could not be attributed to gypsum.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 18 months.
- Frequency of treatment:
- daily
- Post exposure period:
- NR
- No. of animals per sex per dose:
- NR
- Control animals:
- yes, concurrent no treatment
Examinations
- Examinations:
- Changes in lung tissue indicate unspecific bronchiolitis present also in controls. No foreign body accumulation would be observed in lung tissue or in hilus lymph nodes.
Results and discussion
- Details on results:
- Long-term investigations have been carried out on Wistar rats for up to 18 months. Changes in lung tissue indicate unspecific bronchiolitis present also in controls. No foreign body accumulation would be observed in lung tissue or in hilus lymph nodes. A diffuse increase in the interstitial connective tissue was not proven. A cytotoxicological effect could not be attributed to gypsum.
Applicant's summary and conclusion
- Conclusions:
- Long-term investigations have been carried out on Wistar rats for up to 18 months. Changes in lung tissue indicate unspecific bronchiolitis present also in controls. No foreign body accumulation would be observed in lung tissue or in hilus lymph nodes. A diffuse increase in the interstitial connective tissue was not proven. A cytotoxicological effect could not be attributed to gypsum.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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