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EC number: 201-983-0 | CAS number: 90-30-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Taking into account all available data, N-phenyl-1-naphthylamine was found not to be irritating to the skin.
Under the experimental conditions, the test material was not considered to be an eye irritant since slight conjunctivitis was fully reversible within 10 days.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- The experiments reported herein were conducted according to the "Guide for the Care and Use of Laboratory Animals", DHEW 78-23. Rabbits were tested according to the methods described by Draize et al., (1944) to determine primary skin irritation potential for the test material.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0-3.0 kg - Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period:
- 24 and 72 hours
- Number of animals:
- 6
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Remarks on result:
- other: no irritation effects
- Interpretation of results:
- other: EU GHS criteria not met
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study (OECD), but intended for evaluation for skin sensitization
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 406
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method B.6
- Deviations:
- no
- Principles of method if other than guideline:
- This test was a preliminary test intended to find the Pre-Maximum Non Irritant Concentration (M.N.I.C.) for the main skin sensitization study (7.4.1 Richeux, 203).
- GLP compliance:
- yes (incl. QA statement)
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Centre de Production Animale (F-45160 Olivet)
- Weight at study initiation: mean 449.8 g (males), 428.4 g (females)
- Diet (e.g. ad libitum): Guinea Pig Breeding Diet, Cobayes-Elevage
- Acclimation period: 5 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 26 - 61 - Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: praffin oil
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no information given
- Concentration (if solution): 12.5%, 25%, 50%, 100% - Duration of treatment / exposure:
- 24 h
- Observation period:
- 24 h
- Number of animals:
- 2
- Details on study design:
- This test was a preliminary test intended to find the Pre-Maximum Non Irritant Concentration (M.N.I.C.) for the main skin sensitization study (7.4.1 Richeux, 203).
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Concentration: 100%
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Remarks on result:
- other: Concentration: 12.5%, 25%, 50%
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Remarks on result:
- other: Concentration: 12.5%, 25%, 50%
- Irritant / corrosive response data:
- 24 hours after the removal of the occlusive dressings, it was noted a slight erythema on the treated area at 100%. In view of these results, the concentrations selected were 100% for the 2nd induction of the main study and the MNIC began at the concentration of 50%.
- Interpretation of results:
- other: EU GHS cirteria not met
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Primary irritation to the skin is measured by a patch-test technique on the intact skin of albino rabbits.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24, 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: backs of the animals
- % coverage: 2.5 cm2 x2.5 cm2
- Type of wrap if used:
The patches are fixed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material to maintain teh test patechs in position and to retard evaporation of volatile substances.
SCORING SYSTEM: Draize scoring system - Irritation parameter:
- erythema score
- Basis:
- animal: #1, #3, #6
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Remarks on result:
- other: Draize scoring
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Draize scoring
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Draize scoring
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Draize scoring
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2, #3, #5, #6
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Remarks on result:
- other: Draize scoring
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Draize scoring
- Irritation parameter:
- other: scaliness
- Basis:
- animal: #1, #3, #4, #5, #6
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Remarks on result:
- other: CIVO scoring
- Irritation parameter:
- other: scaliness
- Basis:
- animal #2
- Time point:
- other: 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: CIVO scoring
- Interpretation of results:
- other: EU GHS criteria not met
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- N-phenyl-1-napthylamine was applied to the intact skin of rabbits and skin irritation was evaluated after 24 hours after application.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Vehicle:
- other: Carbowax PEG400
- Controls:
- not specified
- Duration of treatment / exposure:
- The test material was not removed.
- Observation period:
- 24 hours
- Number of animals:
- 5
- Irritation parameter:
- other: The test material was slightly irritating to the skin.
- Remarks on result:
- other: 24 hours after application: moderate capillary injection on 2 rabbits, marked injection on 3 rabbits. Therefore, the test material was slightly irritating to the skin.
- Conclusions:
- 24 hours after application: moderate capillary injection on 2 rabbits, marked injection on 3 rabbits. Therefore, the test material was slightly irritating to the skin.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 JUN 1987 to 26 JUN 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- GLP compliance:
- no
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:room temperature - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH-4414 Fuellinsdorf
- Age at study initiation: 12-14 weeks
- Weight at study initiation: 2680 to 3100 g
- Housing: individually in metal cages
- Diet: ad libitum standard rabbit pellet - Nafag No. 814, Gossau, Switzerland
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: the patches were moistened before application with distilled water containing 0.5% carboxymethylcellulose and 0.1% polysorbate 80
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 3 days
- Number of animals:
- 3 male rabbits
- Details on study design:
- TEST SITE
- Area of exposure: flank
- Type of wrap if used: aluminum foil (36 cm ) held in place for 4 hours by an adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
- Time after start of exposure: after 4 hours
OBSERVATION TIME POINTS
1, 24, 48, and 72 hours after removing the gauze patches
SCORING SYSTEM:
- Method of calculation: OECD scoring system - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Slight erythema and edema reactions (score 1) were observed one hour after removing the bandages in one animals. All other readings at 24, 48 and 72h timepoints in all animals were zero.
- Other effects:
- A slight loss of weight was observed in one animal at the end of the observation period on day 3.
- Interpretation of results:
- other: EU GHS criteria not met
- Conclusions:
- Under the experimental conditions employed the test item induced slight erythema and edema reactions when applied to the clipped albino rabbit skin. The reactions were observed only one hour after removing the bandages. Because the mean values of the recordings 24 to 72 hours after application are scored zero, the test item is considered to be not irritating to the skin.
Referenceopen allclose all
24 and 72 hour postexposure examinations of animals tested with N-phenyl-α-naphthylamine failed to demonstrate any irritation effects in the intact skin. There was no evidence of erythema or eschar formation which would be indicative of primary irritation.
Pre-Maximum Non Irritant Concentration (M.N.I.C.) determination:
Macroscopic evaluation of cutanous reaction:
Animal | Concentration (%) | |||
100 | 50 | 25 | 12.5 | |
1 | 1 | 0 | 0 | 0 |
2 | 1 | 0 | 0 | 0 |
skin irritation scores:
24 hours | 24 hours | 72 hours | |
rabbit no. | erythema (Draize scoring) | edema (Draize scoring) | scaliness (CIVO scoring) |
1 | 0 | 0 | 0 |
2 | 1 | 0 | 1 |
3 | 0 | 0 | 0 |
4 | 2 | 2 | 0 |
5 | 1 | 0 | 0 |
6 | 0 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH-4414 Fuellinsdorf
- Age at study initiation: approx. 12-14 weeks
- Weight at study initiation: 2510 to 2520 g
- Housing: The animals were housed individually in metal cages.
- Diet (e.g. ad libitum): standard rabbit pellet (Nafag No. 814, Switzerland); ad libitum; All batches of the diet are assayed for nutritive ingredients and contaminant level by the manufacturer.
- Water (e.g. ad libitum): fresh water; ad libitum; The quality of the drinking water was according to the specifications of the "Schweizerisches Lebensmittelbuch" (Edition 1972).
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The right eyes of the test animals were used as controls.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL (36 mg) - Duration of treatment / exposure:
- The test material was not removed.
- Observation period (in vivo):
- 1, 24, 48 and 72 hour(s) after the instillation of test material.
- Number of animals or in vitro replicates:
- 3 female rabbits
- Details on study design:
- SCORING SYSTEM: OECD scoring system
TOOL USED TO ASSESS SCORE: slit lamp - Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: no effects
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effects
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effects
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effects
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24h
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24h
- Irritant / corrosive response data:
- All control eyes were negative.
After 1 hour, chemosis was observed in animal #2 and animal #3, but was fully reversible within 24 hours.
Under the experimental condition, the test material was classified as not irritating to eyes. - Other effects:
- A slight loss of body weight was observed in animal #2 on day 3 (table 1).
- Interpretation of results:
- other:
- Remarks:
- EU GHS criteria not met
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: FDA of the United States (Fed. Reg. 28 (119), 5582, 1963)
- Principles of method if other than guideline:
- The techniques of the test are published by the FDA of the United States (Fed. Reg. 28 (119), 5582, 1963) and Draize and Kelley (Drug Cosmet. Industr. 71 (36), 1952).
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- no data
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated eye of the test animals serves as a control.
- Duration of treatment / exposure:
- The test material was not removed.
- Observation period (in vivo):
- 24, 48, 72 hours and 7 days
- Number of animals or in vitro replicates:
- 6
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effects
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #2, #3, #5, #6
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: no effects
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- other: 24, 48, 72 hours
- Score:
- > 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: no effects
- Interpretation of results:
- other:
- Remarks:
- EU GHS criteria not met
Referenceopen allclose all
Table 1: body weights in g
animal no. | #1 | #2 | #3 |
at start of test | 2510 | 2510 | 2520 |
after 3 days | 2550 | 2460 | 2620 |
after 7 days | 2680 | 2610 | 2730 |
after 10 days (end) | 2800 | 2600 (not clear because of the bad copy of the report) | 2880 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The potential of the test substance to cause acute dermal irritation or corrosion was assessed in an in vivo skin irritation study following OECD guideline no. 404 (Ciba-Geig, 1987). A single topical application of 0.5 g of the test substance was administered to the intact skin of 3 New Zealand White rabbits for 4 hours under occlusive dressing. Following removal of the test substance, consecutive readings of the application sites were performed over a period of 72 hours. Untreated skin regions of the same animals served as control. As no skin findings were observed in all animals within 72 hours after removal of the patches, the study was terminated. Under the test conditions chosen and considering the described findings the test compound does not give indication of an irritant property to the skin. Several supporting studies are available showing that the test item has no adverse irritation potential.
Eye irritation
In an OECD 405 guideline compliant study the ocular irritation potential of N-phenyl-1-naphthylamine was determined by instillation of the test material into the conjunctival sac of rabbits. Slight conjunctivitis was observed in 2 of 3 rabbits, but was fully reversible within a maximum of 10 days (Ciba-Geigy, 1987). In a study conducted according to US FDA standards, 24 hours after the test compound had been brought into the eyes of rabbits, slight conjunctivitis was observed in 4 of 6 rabbits and chemosis in 1 of 6 rabbits. After 7 days all eye lesions had recovered completely (TNO, 1977).
Justification for classification or non-classification
Data on skin and eye irritation are conclusive but not sufficient for classification.
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