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Diss Factsheets
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EC number: 201-983-0 | CAS number: 90-30-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Please refer also to Read-Across Statement attached in Section 13
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
In this read-across approach data on Naphthalene (CAS 91-20-3, EC 202-049-5) is used to fill data gaps for N-1-naphthylaniline (CAS 90-30-2, EC 201-983-0), in accordance with Regulation No 1907/2006 (REACH), Annex XI. The basis for this read-across approach is the “Read-Across Assessment Framework” (RAAF) (ECHA 2017). The read-across hypothesis for the analogue approach is that N-1-naphthylaniline and Naphthalene exhibit a comparable ecotoxicological hazardous potential as a consequence of structural similarity. The target substance N-1-naphthylamine is a member of Naphthalenes, with the Naphthalene structure being part of the molecule, representing a relevant structure in terms of their ecotoxicological effects. The differences in the molecular structure and the associated differences in physical properties explain the slight differences in the potency of the substance. Nonetheless, from a regulatory point of view, the degree of danger of both substances is comparable.
According to the RAAF this approach is covered by scenario 2, based on “different compounds with qualitatively similar properties”.
“This scenario covers the analogue approach for which the hypothesis is based on different compounds with the same type of effect(s). For the REACH information requirement under consideration, the effects obtained in a study conducted with one source substance are used to predict the effects that would be observed in a study with the target substance if it were to be conducted. The same type of effect(s) or absence of effect is predicted. The predicted strength of the effects may be similar or based on a worst-case approach.”
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Target chemical:
N-1-naphthylaniline, CAS number: 90-30-2, EC number: 201-983-0, Molecular formula: C16H13N, Molecular weight: 219.28 g/mol
Source chemical:
Naphthalene, CAS: 91-20-3, EC number: 202-049-5, Molecular formula: C10H8, Molecular weight: 128.17 g/mol
3. ANALOGUE APPROACH JUSTIFICATION
QSAR profiling reveal no significant differences between the source Naphthalene and the target substance N-1-naphthylaniline, the available data show a comparability of the relevant physico-chemical parameters and a similarity in the ecotoxicological profile, what justifies this read across. Thus, the available studies for the source substances Naphthalene are used to fill data gaps N-1-naphthylaniline for the following ecotoxicological endpoints: Toxicity to sediment organisms, Toxicity to soil microorganisms except arthropods, Toxicity to terrestrial arthropods, Toxicity to terrestrial plants and Toxicity to birds (for further details please refer to attached Read-Across Statement in Section 13).
4. DATA MATRIX
(please refer to attached Read-Across Statement in Section 13) - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 220 other: µmol/kg soil dw
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 28 d
- Dose descriptor:
- EC100
- Effect conc.:
- 2 045 other: µmol/kg soil dw
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Results with reference substance (positive control):
- not applicable
- Validity criteria fulfilled:
- not specified
Reference
Analytical results:
Day 0: 80 to 105% recovery of naphthalene
Day 10: 7 to 20% recovery of naphthalene
Solvent controls showed no effects of solvent on results.
Description of key information
NOEC (28d) = 220 µmol/kg soil dw (measured initial, vehicle) for Enchytraeus crypticus (OECD 220, read across)
Key value for chemical safety assessment
Additional information
No data are available for the toxicity of N-phenyl-1-naphthylamine to terrestrial organisms. Therefore, information from a supporting, structurally analogue compound (naphthalene) was taken into account.
In this key study, the toxicity of naphthalene (purity >99.0%) to Enchytraeus crypticus was tested following OECD guideline 220 (deviation: study duration, no removal of adults before counting, extraction of animals from soil with 96% ethanol, Droge et al. 2006). Nominal concentrations of 62.5, 125, 250, 500 and 1000 mg/kg were tested, with acetone as solvent. For enchytraeids initially 0.4 to 0.6 cm in length, the adult mortality and the number of produced juveniles was recorded after a four-week period. The NOEC (28d) is determined to be 220 µmol/kg soil dw and the EC100 is determined to be 2045 µmol/kg soil dw for mortality and reproductive output. A LC50 value could not be determined since two consecutive concentrations resulted in no effect and a complete effect.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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