Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-983-0 | CAS number: 90-30-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- other: epidemiological study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- A cohort study on cancer among workers exposed to an antirust oil.
- Author:
- Järvholm, B. and Lavenius, B.
- Year:
- 1 981
- Bibliographic source:
- Scand J Work Environ Health 7: 179-184
Materials and methods
- Study type:
- cohort study (retrospective)
- Endpoint addressed:
- carcinogenicity
- Principles of method if other than guideline:
- A cohort study on cancer among workers exposed to an antirust oil containing N-phenyl-1-naphthylamine: an epidemiologic study in an engineeringcompany was prompted by the observation of three cases of cancers.
- GLP compliance:
- no
Test material
- Reference substance name:
- N-1-naphthylaniline
- EC Number:
- 201-983-0
- EC Name:
- N-1-naphthylaniline
- Cas Number:
- 90-30-2
- Molecular formula:
- C16H13N
- IUPAC Name:
- N-phenylnaphthalen-1-amine
- Details on test material:
- - Name of test material (as cited in study report): N-phenyl-1-naphthylamine
- Analytical purity: no data
Constituent 1
Method
- Details on study design:
- HYPOTHESIS TESTED: There has been concern about cancer hazards from various industrial chemicals, among them oils with various contaminantsand additives. Therefore, when it was reported that three cases of cancer had occured among the personnel in a rather small department, this study was initiated to delineate further the mortality pattern among the employees.
METHOD OF DATA COLLECTION
- Details: By means of the personnel register all those individuals were identified.
STUDY PERIOD: 1954-1957 (oocupational); individuals were traced in the parish records through 1976.
STUDY POPULATION
- Selection criteria: Individuals had worked at any time between 1954 and 1957 in the department where the three original cases of cancer were observed and where the sepcific oil had been used (group A)
- Sex and age: Group A was composed of 78 women and 20 men. The study comprised persons born between 1893 and 1942.
- Total number of subjects participating in study: 162
- Total number of subjects at end of study: 162
COMPARISON POPULATION
- Type: Control or reference group / Other comparison group: Groups B/C
- Details: Referents were obtained from another packing department where the specific oil not had been used (group B). The antirust oil had also beenused at some other workplaces within the company, and some individuals were sensitized briefly after its introduction in 1954. Those who became sensitized and had medical treatment for eczema were registered in 1955 and entered on a list. These individuals from various departments were tested by a dermatologist in 1954 and 1955 and according to a letter from 1955 "half of them were allergic to N-phenyl-1-naphthylamine". The individuals on this list constituted group C.
Group B contained 27 women and 8 men. Group C constituted 23 men and 8 women.
HEALTH EFFECTS STUDIED
- Disease(s): cancer incidence
OTHER DESCRIPTIVE INFORMATION ABOUT STUDY: The potential influence of random variation on the difference between observed and expected incidence was described through the calculation of p-values on the Poisson distribution; only two-tailed p-values below 0.05 are indicated. - Exposure assessment:
- estimated
Results and discussion
- Results:
- FINDINGS
Twelve women but no men in group A were found in the Cancer Register. All cancers were diagnosed between 1964 and 1973, and the cancer morbidity for the women was considerably increased. Mortality was also increased for the women, but the entire increase was explained by an increased mortality from cancer. In groups B and C there was no increased cancer morbidity or increased mortality. Two of the workers in group C developed cancer of the bladder, one of whom (a woman) was also included in group A. - Confounding factors:
- Smoking and lifestyle characteristic; other chemicals
- Strengths and weaknesses:
- It is not clear from what chemical and/or environmental conditions the cancer cases were caused. Exposure conditions and possibilities are hypothesized. Groups B and C were small, and the outcome of these groups must therefore be interpereted as "nonpositive" rather than negative.
Any other information on results incl. tables
Composition of the investigated anti-rust oil used by groups A and C:
Substance |
Concentration |
White spirit |
50.0 % |
Mineral oil (acid refined) |
16.5 % |
Lanolin |
16.5 % |
Zinc naphthenate |
16.5 % |
N-phenyl-1-naphthylamine |
0.5 %a |
a: Originally the content was 2.0 %, but the concentration was lowered after a few months because of skin problems.
Morbidity from cancer and mortality in the different groups allowing for a latency period of at least 5 years:
|
Observed |
Expected |
Rate ratio |
95 % confidence interval of the rate ratioc |
Group A Women |
||||
Morbidity from cancer |
12** |
3.9 |
3.1 |
1.6-5.4 |
Mortality from all causes |
8 |
4.3 |
1.9 |
0.8-3.7 |
Mortality from cancer |
6* |
1.7 |
3.5 |
1.3-7.6 |
Men |
||||
Morbidity from cancer |
0 |
0.7 |
0 |
|
Mortality from all causes |
1 |
1.8 |
0.6 |
|
Mortality from cancer |
0 |
0.4 |
0 |
|
Group B |
||||
Morbidity from cancer |
4a |
2.0 |
2 |
|
Mortality from all causes |
1 |
4.4 |
0.2 |
|
Group C |
||||
Morbidity from cancer |
4b |
3.8 |
1.1 |
|
Mortality from all causes |
9 |
10.0 |
0.9 |
0.4-1.7 |
a: Cancer of the collum of the uterus, unclassified tumor of inguen, cancer of the pancreas, and cancer of the breast.
b: Cancer of the stomach, cancer of the pleurae, and two cases of cancer of the bladder.
c: Confidence interval due to a Poisson distribution. Only intervals with expected or observed values of more than 5 are indicated.
* p<0.05, ** p<0.005
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)