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Diss Factsheets
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EC number: 236-675-5 | CAS number: 13463-67-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Chronic data are available for the toxicity of two upgraded ilmenite slags (>80% TiO2) to the nitrification activity of soil microorganisms in a natural soil, and the lowest NOEC amounts to 10,000 mg/kg dw. Regarding the toxicity of TiO2-NP to soil microbes, no differences between treatments with 100 mg n-TiO2/kg (highest test concentration) and the control were observed in nitrogen and carbon transformation tests according to OECD 216 and OECD 217, respectively (Hund-Rinke and Klawonn, 2013; Hund-Rinke et al., 2016).In sum, toxicity data from standard toxicity tests seems to indicate that micro-and nanosized TiO2 has a low potential for toxicity to soil microbes.
Key value for chemical safety assessment
Additional information
Microsized TiO2:
Chronic data are available for the toxicity of two upgraded ilmenite slags (>80% TiO2) to the nitrification activity of soil microorganisms in a natural soil, and the lowest NOEC amounts to 10,000 mg/kg dw.
Upgraded ilmenites (UGI) consist primarily (> 80%) of titanate, i.e., TiO2 with Fe, Al, Si, Mg and other metals, and are poorly soluble and not biodegradable. The transformation/dissolution of 3 UGI products at loadings of up to 100 mg/L over 28 d did not result in any significant release of titanium. Bulk and nano-TiO2 forms are also poorly soluble in environmental media (Brouwers, 2009; Klawonn, 2017 a-f). Based on similarity in composition and the same poor solubility of UGI and TiO2, read-across of ecotoxicological data from UGI to TiO2 is justified.
Nanosized TiO2:
Regarding the toxicity of TiO2-NP (P25 & NM-104) to soil microbes, no differences between treatments with 100 mg n-TiO2/kg (highest test concentration) and the control were observed in nitrogen and carbon transformation tests according to OECD 216 and OECD 217, respectively (Hund-Rinke and Klawonn, 2013; Hund-Rinke et al., 2016).
Data on soil microbial toxicity are also available from a supporting study, in which a non-standard test was performed. After 84 days of cultivating wheat (Triticum ssp.) in a sand-soil mixture spiked with TiO2-NP up to 1000 mg/kg, roots were colonised by AMF, abnormalities in mycorrhizal colonisation could not be observed, and N2O emissions and the amount of extracted DNA were similar to the control (Klingenfuss, 2014).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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