Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-675-5 | CAS number: 13463-67-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to other aquatic organisms
Administrative data
- Endpoint:
- toxicity to other aquatic vertebrates
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remarks'
- Remarks:
- The references contained in this summary entry represent investigations on the effect of bulk titanium dioxide on different aquatic species following short- or long-term exposure, with very limited value for risk assessment purposes. All references do not fulfil the criteria for quality, reliability and adequacy of experimental data for the fulfilment of data requirements under REACH and hazard assessment purposes (ECHA guidance R4 in conjunction with regulation (EC) 1907/2006, Annexes VII-X). The information contained therein were included for information purposes only.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Evaluation of the effects of titanium dioxide nanoparticles on cultured Rana catesbeiana tailfin tissue
- Author:
- Hammond, S.A. et al.
- Year:
- 2 013
- Bibliographic source:
- Front Genet. 2013 Nov 21;4:251
- Reference Type:
- publication
- Title:
- Effect of nanomaterials on the compound action potential of the shore crab, Carcinus maenas
- Author:
- Windeatt, K.M.; Handy, R.D.
- Year:
- 2 013
- Bibliographic source:
- Nanotoxicology 7, 378-388
Materials and methods
- Principles of method if other than guideline:
- Hammond et al. (2013):
test organism: Rana catesbeiana; The effect of micro-sized titanium dioxide on the gene expression of tissue of tadpoles tailfin was investigated after 48 h of incubation.
Windeatt & Handy (2013:
test organism: Carcinus maenas; The effect of titanium dioxide on the single action potential of nerve cells of frogs was investigated by in vitro testing.
Test material
- Reference substance name:
- Titanium dioxide
- EC Number:
- 236-675-5
- EC Name:
- Titanium dioxide
- Cas Number:
- 13463-67-7
- Molecular formula:
- O2Ti
- IUPAC Name:
- dioxotitanium
- Test material form:
- solid: bulk
- Details on test material:
- - Name of tested material:
Windeatt & Handy (2013: titanium dioxide (ACROS, USA, anatase/rutile 75/25)
Hammond et al. (2013): Titanium dioxide (TIONA AT-1, Christal Global, Belgium, anatase)
- Particle size:
Windeatt & Handy (2013: 134.1 ± 42.5 nm
Hammond et al. (2013): 200-220 nm
- Purity:
Windeatt & Handy (2013: 98.0 - 105 %
Hammond et al. (2013): 98.5 %
Constituent 1
Sampling and analysis
- Details on sampling:
- Analytical confirmation of test concentration:
Windeatt & Handy (2013: no
Hammond et al. (2013): no
Test organisms
- Aquatic vertebrate type (other than fish):
- other: Windeatt & Handy (2013: crab, Hammond et al. (2013): frog
- Test organisms (species):
- other: see below
- Details on test organisms:
- TEST ANIMALS
- test organism:
Windeatt & Handy (2013: Carcinus maenas
Hammond et al. (2013): Rana catesbeiana
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Remarks on exposure duration:
- Windeatt & Handy (2013: at least 5 stimulations; Hammond et al. (2013): 48 h
Test conditions
- Nominal and measured concentrations:
- Windeatt & Handy (2013): 0 (control 1 and 2), 1 mg TiO2 NP/L
Hammond et al. (2013): 0 (control), 0.1, 1.0, and 10 nM TiO2
Results and discussion
Effect concentrationsopen allclose all
- Conc. based on:
- other:
- Remarks on result:
- other: Windeatt & Handy (2013: no significant effects were observed
- Conc. based on:
- other:
- Remarks on result:
- other: Hammond et al. (2013): effects on gene expression were observed
Any other information on results incl. tables
All studies have methodological shortcomings so that reported effects cannot be considered reliable and/or relevant for the risk assessment as follows:
Windeatt & Handy (2013): single concentration was tested, in vitro testing of isolated nerve cells is no relevant examination
Hammond et al. (2013):in vitro testing of isolated tissue is no relevant examination
Applicant's summary and conclusion
- Conclusions:
- All studies have methodological shortcomings so that reported effects cannot be considered reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)