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EC number: 247-722-4 | CAS number: 26471-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Department of Transportation, Hazardous Materials Regulations, Federal register Vol. 37, No. 57, March 23, 1972
- Deviations:
- yes
- Remarks:
- No reading after 48 h and 14 days. Occlusive instead of semi-occlusive (worst case).
- GLP compliance:
- no
Test material
- Reference substance name:
- m-tolylidene diisocyanate
- EC Number:
- 247-722-4
- EC Name:
- m-tolylidene diisocyanate
- Cas Number:
- 26471-62-5
- Molecular formula:
- C9H6N2O2
- IUPAC Name:
- 2,4-diisocyanato-1-methylbenzene, 2,6-diisocyanato-1-methylbenzene
- Details on test material:
- Incomplete test substance characterization.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4 h, 24 h, 48 h, 72 h, and 7 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Preparation: Prior to the application of the test material, the hair was clipped from the back and flanks of each rabbit. Two test sites located lateral to the midline of the back approximately 10 cm apart were selected. One site was abraded by making four epidermal incisions, while the other test site remained intact.
- Type of wrap if used: The test sites were covered with two-inch square gauze patches which were secured with masking tape. The trunk of each animal was then wrapped with plastic sheeting.
OBSERVATION TIME POINTS
4, 24, and 72 hours
SCORING SYSTEM:
- Method of calculation:
Scoring for erythema and edema was performed on a graded scale of 0 to 4.
The average irritation was calculated by the mean scores for erythema and edema after 4, 24, and 72 hours.
These values were totaled for abraded and intact skin and divided by six to obtain the mean primary irritation score.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 4/24/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 4/24/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 4/24/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 4/24/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: 4/24/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: 4/24/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 4/24/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 4/24/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 4/24/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 4/24/72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- other: 4/24/72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- other: 4/24/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- After seven days all animals exhibited a grade 2 erythema and a grade 1 to 2 edema with fissuring, fatigued skin and desquamation. No destruction or irreversible changes of the tissue structure were reported.
Any other information on results incl. tables
4-hour exp. animal # |
abraded skin |
intact skin |
||||||||||
(4 hr) |
(24 hr) |
(72 hr) |
(4 hr) |
(24 hr) |
(72 hr) |
|||||||
ER |
ED |
ER |
ED |
ER |
ED |
ER |
ED |
ER |
ED |
ER |
ED |
|
1 |
2 |
4 |
2 |
2 |
2 |
1 |
2 |
4 |
2 |
2 |
2 |
1 |
2 |
2 |
4 |
2 |
4 |
2 |
1 |
2 |
4 |
2 |
4 |
2 |
1 |
3 |
2 |
4 |
2 |
4 |
2 |
1 |
2 |
4 |
2 |
4 |
2 |
1 |
4 |
2 |
4 |
2 |
3 |
2 |
1 |
2 |
4 |
2 |
3 |
2 |
1 |
5 |
2 |
4 |
2 |
3 |
2 |
2 |
2 |
4 |
2 |
3 |
2 |
1 |
6 |
2 |
4 |
2 |
2 |
2 |
2 |
2 |
4 |
2 |
2 |
2 |
1 |
Mean |
2 |
4 |
2 |
3 |
2 |
1.3 |
2 |
4 |
2 |
3 |
2 |
1 |
(ER = erythema; ED = edema)
Erythema score 1: barely perceptible (edges of area not defined)
Erythema score 2: pale red in color and area definable
Erythema score 3: definite red in color and area well defined
Erythema score 4: beet or crimson red in color
Edema score 1: barely perceptible (edges of area not defined)
Edema score 2: area definable but not raised more than 1 mm
Edema score 3: area well defined and raised approximately 1 mm
Edema score 4: area raised more than 1 mm
Injury In Depth 8: escharosis, necrosis
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
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