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EC number: 247-722-4 | CAS number: 26471-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The study carried out with a loading of 1000mg TDI/l (Kitano et al, 1989) under rapid stirring conditions gave a half-life of ca. 0.7h (corresponding to a rate constant of 1 h-1). This result reflects a more realistic environmental situation. The Yakabe et al (1999) work was carried out under less realistic environmental conditions, using a loading of 28mg TDI/l and with vigorous agitation, leading to a shorter half-life of less than one minute.
Holdren (1983) investigated the hydrolysis in air. Abele and Brochhagen (1976) and Fujiwara (1980), although having created valuable data for incident management, do not provide robust data to calculate the half-life of TDI in water.
The results of Yakabe et al (1999) allows the derivation of a linear regression algorithm for the calculation of the yield of TDA due to high speed stirring of TDI into water.
[TDA] = 0.0606 x log [TDI] + 0.1108; mmol/l.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 h
- at the temperature of:
- 300 K
Additional information
TDI is rapidly hydrolysed in aqueous solution, with a half-life of under one minute (Yakabe et al., 1999). The product of hydrolysis of the isocyanate group is an amine, which itself reacts with another isocyanate group to yield a urea. This reaction of an amine with isocyanate is considerably faster than the reaction of water with the isocyanate (Yakabe et al, 1999). With TDI, a diisocyanate, this reaction leads to polyureas, which are inert, insoluble solids.Tests with wet soil have demonstrated that the hydrolytic self-polymerization of TDI is the predominant reason for TDI disappearance in this compartment (Blumencron, 1978).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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