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EC number: 247-722-4 | CAS number: 26471-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
- Reference Type:
- publication
- Title:
- Toxicology, industrial hygiene and medical control of TDI, MDI and PMPPI
- Author:
- Woolrich PF
- Year:
- 1 982
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 43 (2): 89-97
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Two rabbits/sex instead of 5 were tested per group. The skin of half the rabbits in each group was abraded by producing shallow incisions with a scalpel blade.TDI isomer ratio and purity not specified.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- m-tolylidene diisocyanate
- EC Number:
- 247-722-4
- EC Name:
- m-tolylidene diisocyanate
- Cas Number:
- 26471-62-5
- Molecular formula:
- C9H6N2O2
- IUPAC Name:
- 2,4-diisocyanato-1-methylbenzene, 2,6-diisocyanato-1-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Toluene diisocyanate
- Physical state: clear slightly viscous oily liquid
- Analytical purity: considered to be free of impurities
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2215 - 3180 g
- Housing: individually in metal cages
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: ~ 3 inches²
- Type of wrap if used: non-occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 h
TEST MATERIAL
- Amounts applied: doses of 2500 - 9400 mg/kg
OTHER
TDI applied undiluted to intact or abraded skin of 2 male and 2 female rabbits at doses of 2500 - 9400 mg/kg. The dorsal skin of each rabbit was prepared for treatment by close clipping of the hair with an electric clipper. In addition, the skin of half the rabbits in each group was abraded by producing shallow incisions with a scalpel blade over an area approximately three inches square. The compound was applied to each individual animals in the liquid form as received and administered on a volume basis. The animals were observed daily for a total of 14 days for pharmacotoxic signs and dermal irritation. Body weights were obtained for each animal and a complete necropsy was performed on each animal at termination. - Duration of exposure:
- 24 h
- Doses:
- 2500, 3900, 6000, and 9400 mg/kg bw
- No. of animals per sex per dose:
- Four groups of 4 rabbits (2/sex) were used.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations (1) and weighing (2):
(1) Observations occured daily
(2) weighing occured at the beginning and at the end of the study.
- Necropsy of survivors performed: yes
- Other examinations performed: Signs of dermal irritation
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 9 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: All animals appeared essentially normal throughout the 14-day observation period.
- Gross pathology:
- All animals at all dosage levels were considered essentially normal at necropsy examination. No potential target organs were observed. No apparent difference between the sexes was observed.
- Other findings:
- - Other observations: Dermal irritation was seen at each of the four dosage levels. Peak irritation occurred between the 5th and 10th day after application. During this time, erythema, edema, atonia, and coriaceousness were observed in most cases to a moderate-to-marked degree. From the 8th to the 14th day, moderate-to-marked desquamation and fissuring were observed. This condition subsided by the termination of the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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