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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 206-114-9 | CAS number: 302-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: determination of reproduction organ weights in a 28 day repeated dose toicity study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD TG 407
- Deviations:
- yes
- Remarks:
- 14 day recovery period (control and highest dose group=
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- hydrazine monohydrate
- Cas Number:
- 7803-57-8
- Molecular formula:
- H4N2*H2O
- IUPAC Name:
- hydrazine monohydrate
- Reference substance name:
- hydrazine hydrate, 64 %
- IUPAC Name:
- hydrazine hydrate, 64 %
- Details on test material:
- IUCLID4 Test substance: other TS: hydrazine monohydrate, purity: 100.15 %
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Crj: CD (SD)IGS
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- see section 7.5.1
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- see section 7.5.1
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- see section 7.5.1
- Frequency of treatment:
- see section 7.5.1
- Duration of test:
- 28 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1, 3, 10, 30 mg/kg bw/d
Basis:
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- dose level:
- Effect level:
- ca. 30 mg/kg bw/day
- Sex:
- male
- Basis for effect level:
- other: significant decreased absolute weight of epididymis
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 30 mg/kg bw/day
- Sex:
- female
Observed effects
Any other information on results incl. tables
male rats:
after treatment for 28 days there was a dose related decrease in mean absolute weight of epididymides which
was significant at 30 mg/kg bw; recovery after 14 days
no changes in relative weights
no other effects observed
female rats:
there were no difference in absolute or relative weights of ovaries when compared to the respective controls
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.