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Diss Factsheets
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EC number: 206-114-9 | CAS number: 302-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- specially designed to characterise the degradation behaviour of the substance in natural surface water.
- Principles of method if other than guideline:
- Surface water from a natural pond and the river Rhine were collected and immedatialy spiked with Hydrazine in the laboratory. The test vessels were stirred under aerobic conditions and a light regime. Hydrazine was measured photometrically at different time periods. Photometry, determination of Hydrazine according to DIN 38413-P1.
- GLP compliance:
- no
- Remarks:
- The experiment was specially designed to characterise the degradation behaviour of the substance in natural surface water.
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Two sampling sites close to Leverkusen City (Germany) were selected to take the surface water samples needed for this study: a wet gravel pit, east of Leverkusen, immediately adjacent to the Autobahn A3, and the eastern bank of the Rhine river at Leverkusen-Hitdorf (north of Leverkusen City). Samples were taken from the river bank, or gravel pit bank, using a water sampler, and were subsequently transported to the laboratory without delay.
- Buffers:
- no buffers were used
- Details on test conditions:
- Culturing apparatus : Light chamber in which a temperature in the range 21°C to 24°C was maintained at +/- 2°C, and continuous uniform illumination was provided in the spectral range 400 to 700 nm. Temperature was measured and recorded daily in a water filled flask which was incubated under the same conditions as the test flasks.
Light intensity : At the average of the test solutions, a light intensity in the range 60 to 120 μE. x m-2 x s-1, or an equivalent range of 4000 to 8000 lx, was used.
Test item concentration : 39 μg/L hydrazine hydrate, equalling to 25 μg/L hydrazine
Method of administration : direct weighing
Duration of exposure : 48 hours - Duration:
- 48 h
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- >= 24 - <= 27 µg/L
- Statistical methods:
- Calculation of the half lives and the rate constants using the equations for first order kinetics.
- Transformation products:
- not measured
- pH:
- 8.2
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0
- DT50:
- 2.67 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: Wet grevel pit (natural pond water)
- pH:
- 8.1
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0
- DT50:
- 24 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: natural Rhine water
- Executive summary:
A study was performed to assess the stability, or dissipation respectively, of hydrazine hydrate administered to two different surface water samples, over a 48h exposure period under defined laboratory conditions. With initial concentrations of hydrazine hydrate adjusted to 0.0375 mg/L (wet gravel pit sample), or 0.0422 mg/L (Rhine river sample), the test item concentrations dropped below the limit of quantification (photometry: LOQ = 0.0156 mg/L) within 6 to 24 hours. Half life times of 2.67 to 24 hours at 20°C could be calculated.
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Referenceopen allclose all
Degradation of Hydrazine
time (h) | Hydrazine in Gravel pit (mg/L) | Hydrazine in Rhine water (mg/L |
0 | 0.024 | 0.027 |
1.5 | 0.015 | 0.022 |
3 | 0.01 | 0.0185 |
6 | <0.01 | 0.0155 |
24 | <0.01 | 0.012 |
48 | <0.01 | <0.01 |
Description of key information
A guideline test was waived as the substance is marketed as aqueous dilution with varying concentrations of hydrazine, a hydrolytical reaction can be excluded. The disappearance of hydrazine is rather caused by the presence of various water constituents (for example organic matter, oxygen, carbonate, metal ions) than by the presence of water molecules itself. This has been shown by a study where natural surface water (pond water, river water) was spiked with hydrazine. The substance declined rapidly with half lives of 2.6 hours (pond water) and 24 hours (river water) (Sapers 2010). Another study (Slonim 1076) supports these finding, as half-lives for hydrazine in natural surface waters were a few hours, whereas clean tap waters showed higher stability to hydrazine.
Supporting evidence is given by a synopsis of the available literature (Canada hydrazine assessment 2011) where a melange of data is given assessing biodegradation and abiotic degradation.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 24 h
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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