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EC number: 206-114-9 | CAS number: 302-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrazine is corrosive or irritating to the skin of rabbits when applied as 55 % solution or 35 % solution, respectively; in diluted form (5% solution) it causes no irritation to the skin of rabbits and none to the eye of rabbits (Bayer 1988, BUA 1996).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study, GLP, TS 5 % in water
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: adult
- Weight at study initiation: 3.1-3.3 kg
- Housing: individual
- Diet ad libitum
- Water . ad libitum):
- Acclimation period: 14 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20
- Humidity (%): 50
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
- Vehicle:
- other: diluted in water to yield a 5 % solution
- Controls:
- yes
- Amount / concentration applied:
- Amount applied: 0.1 ml
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 3 animals 1 eye as the test eye the other served as control
- Details on study design:
- Comment: rinsed after (see exposure time)
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: score = 0 at any time point
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: score = 0 at any time point
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Irritant / corrosive response data:
- there were no irritational effects observed in none of the animals in test
- Other effects:
- no other effects were reported
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
5 % hydrazine solution was evaluated as non-irritating to the eyes of rabbits when tested according to OECD TG 405.(Bayer AG 1988).
Reference
There were no irritational effects observed in none of the animals in test.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin:
Rabbits were testd with 500 µl of an aquous solution containing 5 % hydrazine for skin irritation according to OECD TG 404. the test substance was evaluated to be non-irritating (Bayer 1988). 35 % Hydrazine solution was tested for its potential to induce dermal corrosion according to the Transportation Regulations for shippers and GLP and was evaluated to be not corrosive but shows irritating effects which were only partly reversible within the observation time of 72 hours (Mobay Chemical Corporation 1984). Application of 55 % hydrazine solution to the clipped skin of rabbits for 4 hours showed the corrosive property of 55 % hydrazine solution (Otsuka Chem Comp. 1978)
The available data show that the effect on the skin changes from non-irritation to irritation and corrosion with increase in the concentration range.
Thus it is plausible that hydrazine can be corrosive at high concentrations.
Eye:
5 % hydrazine solution was evaluated as non-irritating to the eyes of rabbits when tested according to OECD TG 405.(Bayer AG 1988)
Justification for selection of skin irritation / corrosion
endpoint:
There are 3 reliable studies available with increasing
concentrations ranging between 5 and 55 % and evaluated with Klimisch
score 1 and 2.
Justification for selection of eye irritation endpoint:
This is the only availble study which is performed according to the
respective guideline and under GLP condions. Therefore is is evaluated
with Klimisch score 1
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
Under Regulation No 1272/2008 (GHS) the substance is classified as Skin corrosion class 1B, Hazard Statement H314: causes severe skin burns and eye damage: C >= 10 %;
Skin Irritation class 2, Hazard Statement H315: causes skin irritation: 3% <= C < 10, Eye Irritation class, Hazard Statement H319 causes severe eye irritation: 3 % <= C <10 %
In general, this classification is in line with the available data.
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