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EC number: 206-114-9 | CAS number: 302-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: results presented as graphics only
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
- Principles of method if other than guideline:
- hydrazin solutions in various aqueous concentrations were applied to the skin of rabbits over selected time periods and serum hydrazin concentrations were determined
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydrazine
- EC Number:
- 206-114-9
- EC Name:
- Hydrazine
- Cas Number:
- 302-01-2
- Molecular formula:
- H4N2
- IUPAC Name:
- hydrazine
- Details on test material:
- anhydrous hydrazine, hydrazine 70 %,, hydrazine 15 % and 2 % hydrazine solution
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: no vehicle or water
- Duration of exposure:
- up to 12 minutes
- Doses:
- Anhydrous hydrazine, hydrazine 70 %,, hydrazine 15 % and 2 % hydrazine solution.
- No. of animals per group:
- no data
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- yes
- Absorption in different matrices:
- for available information see section remarks on results
- Total recovery:
- for available information see section remarks on results
Any other information on results incl. tables
RM-Freetext: (graphics only)
Result: time-limitation of percutaneous Hz exposure (2, 6, 12 minutes)
demonstrated a direct correlation between duration of exposure and peak
serum. Hydrazine concentrations for both Hz and Hz70%. A correlation of
time to peak serum Hz level with duration of Hz exposure was also
evident with anhydrous Hz but not Hz70%. Serun Hz levels peaked at 50
-90 min for anhydrous Hz and at 30 -50 min for Hz70%. Total percutaneous
Hz absorption from anhydrous Hz or Hz70% was also directly related to
duration of Hz exposure. In addition the rate of Hz absorption was
greater for anhydrous Hz than for Hz70% . The peak serum Hz
concentration was greater for Hz15% than for Hz2%. These peak serum Hz
concentration occurred at 30 min for Hz15% and at 10 min for Hz2%. There
was an increase in the percent Hz dose absorbed as the Hz solution
concentration increased. tissue evaluation: severe chemical burns were
found in rabbits percutaneously exposed to annydrous Hz or Hz70%. These
lesions typically contained areas of transepidermal necrosis with
varying degrees of dermal necrosis. No significant lesions were noter
following percutaneous exposure to Hz15% or Hz2%.
Applicant's summary and conclusion
- Executive summary:
Hydrazin is absorbed through the skin of rabbits (Keller 1984).
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