Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-778-1 | CAS number: 7726-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Toxicological information
Toxicity to reproduction
Currently viewing:
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on generations indicated in Effect levels (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of Sodium Bromide in Rats: Effects on Endocrine System and Reproduction
- Author:
- Van Leeuwen F.X.R., Den Tonkelaar E.M. and Van Logten M.J.
- Year:
- 1 983
- Bibliographic source:
- Fd. Chem. Toxic., 1983, Vol. 21 no 4, 383-389.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other
- Principles of method if other than guideline:
- Study was not based on standard protocol.
Every generation was mated twice (F0 generation mated 4 times):
F0 -> F1a, F1b (further mated), F1c (for transplacental Br transport study), F1d (reversibility study)
F1b -> F2a, F2b (further mated)
F2b -> F3a, F3b
Mating of F1 and F2 generations was not performed for the 4800 or 19200 mg/kg (diet)/day dose groups. - GLP compliance:
- no
Test material
- Reference substance name:
- Sodium bromide
- EC Number:
- 231-599-9
- EC Name:
- Sodium bromide
- Cas Number:
- 7647-15-6
- IUPAC Name:
- sodium bromide
- Details on test material:
- Sodium bromide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no further details
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: Diet
- Details on exposure:
- In food
Plain diet - Details on mating procedure:
- Study was not based on standard protocol.
Every generation was mated twice (F0 generation mated 4 times):
F0 -> F1a, F1b (further mated), F1c (for transplacental Br transport study), F1d (reversibility study)
F1b -> F2a, F2b (further mated)
F2b -> F3a, F3b
Mating of F1 and F2 generations was not performed for the 4800 or 19200 mg/kg (diet)/day dose groups. - Analytical verification of doses or concentrations:
- no
- Details on analytical verification of doses or concentrations:
- no further details
- Duration of treatment / exposure:
- Exposure period: Three generations
- Frequency of treatment:
- Daily
- Details on study schedule:
- no further details
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 75, 300, 1200, 4800, 19200 ppm
Basis:
nominal in diet
- No. of animals per sex per dose:
- Males: 9-10 per group (F0) or 10 per group (F1, F2).
Females: 7-12 per group (F0), 14-19 per group (F1), 10 per group (F2) - Control animals:
- yes, concurrent no treatment
- Details on study design:
- no further details
- Positive control:
- no
Examinations
- Parental animals: Observations and examinations:
- Unknown method
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 300 ppm
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 1 200 ppm
Results: F2 generation
Effect levels (F2)
- Dose descriptor:
- NOAEL
- Generation:
- F2
- Effect level:
- 1 200 ppm
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables