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Diss Factsheets
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EC number: 231-778-1 | CAS number: 7726-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference in a foreign language, and not yet available
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Halogens on an Organism
- Author:
- Tswapo V V, VN Kupyrov, RK Gakol et al.
- Year:
- 1 975
- Bibliographic source:
- Gig Sanit 6:92-93 English summary from Chem Abstr 83:14261r
Materials and methods
- Principles of method if other than guideline:
- Rats were given bromine in drinking water. Behavioral and reflex observations, blood and blood chemistry analysis, examination of internal organs were conducted.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Bromine
- EC Number:
- 231-778-1
- EC Name:
- Bromine
- Cas Number:
- 7726-95-6
- Molecular formula:
- Br2
- IUPAC Name:
- dibromine
- Details on test material:
- Although this study cites bromine as the test article, when addded to drinking water, elemental bromine is not likely to be present. The test article, thus, would actually be hypobromous acid and other brominated oxidants formed.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: drinking water
- Duration of treatment / exposure:
- Six month exposure
- Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.01 mg/kg
Basis:
nominal in water
- Remarks:
- Doses / Concentrations:
Unspecified lower doses
Basis:
nominal in water
Results and discussion
Results of examinations
- Details on results:
- Reported effects included altered behavior, decreased erythrocyte and leukocyte counts, decreased hemoglobin levels, lower cholinesterase and alkaline phosphatase activity, decreased phagocytic action of neutrophils, and increased ascorbate content of the adrenal glands. Unspecified lower doses of bromine did not significantly alter conditioned reflexes, blood indicies or internal organs.
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 0.01 mg/kg bw/day (nominal)
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a 6 month study with rats given 0.01 mg/kg bromine in drinking water, reported effects included altered behavior, decreased erythrocyte and leukocyte counts, decreased hemoglobin levels, lower cholinesterase and alkaline phosphatase activity, decreased phagocytic action of neutrophils, and increased ascorbate content of the adrenal glands. Unspecified lower doses of bronime did not significantly alter conditioned reflexes, blood indicies or internal organs.
- Executive summary:
In a 6 month study with rats given 0.01 mg/kg bromine in drinking water, reported effects included altered behavior, decreased erythrocyte and leukocyte counts, decreased hemoglobin levels, lower cholinesterase and alkaline phosphatase activity, decreased phagocytic action of neutrophils, and increased ascorbate content of the adrenal glands. Unspecified lower doses of bronime did not significantly alter conditioned reflexes, blood indicies or internal organs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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