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Diss Factsheets
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EC number: 202-974-4 | CAS number: 101-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- Proliferation ductulaire biliaire intra-hepatique chez la ratte gestante traitee par le 4,4'-diaminodiphenyl-methane(4,4DDPM)
- Author:
- Bourdelat D, Moulinoux JP, Chambon Y & Babut JM
- Year:
- 1 983
- Bibliographic source:
- Bull.Assoc.Anal. (Nancy) 67: 375-82
Materials and methods
Test guideline
- Qualifier:
- no guideline available
Test material
- Reference substance name:
- 4,4'-methylenedianilinium dichloride
- EC Number:
- 236-934-2
- EC Name:
- 4,4'-methylenedianilinium dichloride
- Cas Number:
- 13552-44-8
- Molecular formula:
- C13H14N2.2ClH
- IUPAC Name:
- 4,4'-methylenedianilinium dichloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Days 7-20 and 14-20
- Frequency of treatment:
- Daily
- Duration of test:
- 21 days
Doses / concentrationsopen allclose all
- Dose / conc.:
- 75 other: mg (300 mg/kg)/d
- Dose / conc.:
- 12 other: mg (50 mg/kg)/
- No. of animals per sex per dose:
- 75 mg (300 mg/kg)/day; 5 animals
12 mg (50 mg/kg)/day; 10 animals
(5 animals/cage dose groups, one animal in control group) - Control animals:
- yes, concurrent no treatment
- Details on study design:
- The rats with an average weight of 260 g, were housed 5/cage, and given food and water ad libitum. There was a single control rat which received distilled water. The rats were sacrificed 24 hr before delivery. The maternal livers were examined macroscopically, and the foetuses were dissected.
Examinations
- Maternal examinations:
- Hepatic lesions were observed in mothers.
- Fetal examinations:
- The macroscopic, and microscopic, hepatic lesions in the foetus were examined.
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
Hepatic lesions
Effect levels (maternal animals)
- Key result
- Dose descriptor:
- other: not given
- Basis for effect level:
- histopathology: non-neoplastic
- Remarks on result:
- not determinable
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Macroscopic, and microscopic hepatic lesions in the foetus were observed. At the higher dose there were sometimes neural tube defects without hepatic lesions.
Applicant's summary and conclusion
- Conclusions:
- Hepatic lesions were observed in the mothers, and in some cases there were macroscopic and microscopic hepatic lesions in the foetus. At the higher dose there were sometimes neural tube defects without hepatic lesions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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