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Diss Factsheets
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EC number: 202-974-4 | CAS number: 101-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 222 (Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- The stock solution was prepared in ethanol. An appropriate amount of the stock and the dosage solutions, respectively was used to soak a
portion of the quartz sand of the artificial soil. After evaporation of the solvent by placing under a fume hood, the quartz sand was incorporated into the remainders of the artificial soil to prepare the different test item soil concentrations. - Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: Earthworms
- Source: ECT Oekotoxikologie GmbH since February 1994; originally delivered by Co. Landenberger (72355 Schömberg, Germany)
- Age at test initiation (mean and range, SD): 2 - 12 months
- Weight at test initiation (mean and range, SD): 300 - 600 mg
ACCLIMATION
- Acclimation period: 2 days
- Acclimation conditions (same as test or not): same as test
- Health during acclimation (any mortality observed): healthy - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 56 d
- Test temperature:
- 18.3 – 21.6 °C
- pH:
- 20 ± 2 ºC
- Moisture:
- 50.7 - 59.9 % of WHCmax
- Nominal and measured concentrations:
- Concentrations tested: Solvent control, control; 18.0, 32.0, 56.0, 100, 180 and 320 mg test item/kg artificial soil (dw).
Measured 95.3 - 97.7 % of nominal in the test solution of the highest concentration. - Reference substance (positive control):
- yes
- Remarks:
- Carbendazim
- Duration:
- 56 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 18 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 56 d
- Dose descriptor:
- EC10
- Effect conc.:
- 11.2 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
Reference
Description of key information
An experimental study with Eisenia fetida predicted an EC10 of 11.2 mg/kg soil dw, after 56 d exposure to the test item
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 11.2 mg/kg soil dw
Additional information
An experimental study with Eisenia fetida according to OECD guideline 222 and GLP regulations assessed the long-term toxicity of the test item to soil macroorganisms. An EC10 of 11.2 mg/kg soil dw was obtained after 56 d exposure time based on the reproduction of the test species (ECT, 2012). A supporting study with the same species but a short exposure period and a higher maximal test concentration revealed a NOEC of 180 mg/kg soil dw and an EC50 of 444 mg/kg soil dw (TNO, 1992). Since these results are based only on nominal concentrations and no analytical monitoring was conducted, they are only used as supporting data which give a hint for a possible lower toxicity of the test item to soil macroogranism than predicted by the ECT study. Assuming the worst-case further assessments are made based on the ECT results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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