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Diss Factsheets
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EC number: 236-068-5 | CAS number: 13138-45-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03/06/2003-24/06/2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted guidelines with some limitations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Environmental parameters: A relative humidity of 72% was recorded in the course of this study rather than 70% (maximum limit) as stated in the experimental protocol,
A temperature of 25°C was recorded in the course of this study rather than 23°C (maximum limit) as stated in the experimental protocol.
These deviations did not in any event affect the performance and the results of this study. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Nickel nitrate cryst 6H20
- IUPAC Name:
- Nickel nitrate cryst 6H20
- Reference substance name:
- Nickel dinitrate
- EC Number:
- 236-068-5
- EC Name:
- Nickel dinitrate
- Cas Number:
- 13138-45-9
- Molecular formula:
- Ni(NO3)2
- IUPAC Name:
- nickel(2+) dinitrate
- Details on test material:
- - Name of test material (as cited in study report): NICKEL NITRATE CRYST 6H20
- Physical state: solid powder
- Lot/batch No.: 8115 TQ
- Storage condition of test material: ambient temperature
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMAL
- Source: Elevage de Gérome (Quartier Labaste - 40260 Linxe)
- Weight at study initiation: 2.19-2.23 kg
- Housing: individual cage
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):19-25
- Humidity (%): 58-72
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other eye of same animals
- Amount / concentration applied:
- 0.1g
- Duration of treatment / exposure:
- not reported
- Observation period (in vivo):
- 1, 24, and 48 hours
- Number of animals or in vitro replicates:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Maxiumum Eye Irritation Index (I.O. Max)
- Basis:
- animal: A5362
- Time point:
- other: Through day 22
- Score:
- >= 13 - <= 82
- Max. score:
- 82
- Reversibility:
- not fully reversible within: D21 (end of observation period)
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: A5362
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 22 days
- Irritation parameter:
- iris score
- Basis:
- animal: A5362
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- enanthema (rash)
- Basis:
- animal: A5362
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 22 days
- Irritation parameter:
- chemosis score
- Basis:
- animal: A5362
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not fully reversible within: 22 days
- Irritation parameter:
- chemosis score
- Basis:
- animal: A5362
- Time point:
- 48 h
- Score:
- 3
- Reversibility:
- not fully reversible within: 22 days
- Irritation parameter:
- chemosis score
- Basis:
- animal: A5362
- Time point:
- 72 h
- Score:
- 3
- Reversibility:
- not fully reversible within: 22 days
- Irritant / corrosive response data:
- Moderate to significant eye effects that were partially reversible were noted, namely:
- at the level of the conjunctiva: a moderate enanthema noted 1 hour after the instillation of the product and still noted at the end of the observation period (D21) (mild intensity), associated with a significant chemosis, noted 1 hour after the instillation of the product and still noted at the end of the observation period (D21) (moderate intensity),
- at the level of the cornea: a moderate opacity, noted 24 hours after the instillation of the product and still noted at the end of the observation period (D21) (mild intensity),
- at the level of the iris: mild congestion was noted from the 1st to the 5th day, followed significant congestion from the 6th to the 17th day of the study.
Furthermore, these effects are accompanied by a purulent secretion requiring rinsing with physiological solution from the 2nd to 17th day of the study.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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