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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-068-5 | CAS number: 13138-45-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Meets generally accepted scientific methods with sufficient documentation. Relevant exposure to submission substance, adequate detail on exposure and sampling methods. (A detailed description of the scoring criteria can be found in the .pdf document attached to the 'Exposure Scoring Rationale Document' record at the beginning of Section 7.10.5).
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
- Type of study / information:
- Examination of Ni exposure in at American Cyanamid, Indiana, USA
- Endpoint addressed:
- not applicable
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No standard guideline followed. Details of study provided below.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nickel dinitrate
- EC Number:
- 236-068-5
- EC Name:
- Nickel dinitrate
- Cas Number:
- 13138-45-9
- Molecular formula:
- Ni(NO3)2
- IUPAC Name:
- nickel(2+) dinitrate
- Details on test material:
- - Name of test material (as cited in study report): Nickel dinitrate
- Molecular formula (if other than submission substance): not different than submission substance
- Molecular weight (if other than submission substance): not different than submission substance
- Smiles notation (if other than submission substance): not different than submission substance
- InChl (if other than submission substance): not different than submission substance
- Structural formula attached as image file (if other than submission substance): not different than submission substance
- Substance type: nickel oxide powders
- Other details on test material not reported or not applicable
Constituent 1
Method
- Ethical approval:
- not applicable
- Details on study design:
- NIOSH responded to a request for investigation of Nickel exposure at the American Cyanamid Plant in Michigan City, Indiana. Air samples were
collected and analyzed for 28 metals including nickel. - Exposure assessment:
- measured
- Details on exposure:
- TYPE OF EXPOSURE: airborne exposure to nickel powders and dusts
TYPE OF EXPOSURE MEASUREMENT: Area air sampling and personal sampling, Ni speciation not conducted.
EXPOSURE LEVELS: 0.004 to 0.29 mg/m3 total Ni
EXPOSURE PERIOD: sample time between 352 and 462 minutes
POSTEXPOSURE PERIOD: none
DESCRIPTION / DELINEATION OF EXPOSURE GROUPS / CATEGORIES: none
Results and discussion
- Results:
- Ni exposure exceeded the NIOSH recommended exposure limit (0.015 mg/m3)
Applicant's summary and conclusion
- Conclusions:
- Ni concentrations ranged between 0.004 to 0.29 mg/m3 total Ni.
- Executive summary:
STUDY RATED BY AN INDEPENDENT REVIEWER.
(A detailed description of the scoring criteria can be found in the .pdf document attached to the 'Exposure Scoring Rationale Document' record at the beginning of Section 7.10.5).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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