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Diss Factsheets
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EC number: 231-639-5 | CAS number: 7664-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-standard published study
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhalation Of Sulfuric Acid Mist By Human Subjects
- Author:
- Amdur MO, Silverman L & Drinker P
- Year:
- 1 952
- Bibliographic source:
- Archives of Industrial Hygiene and Occupational Medicine, Vol. 6, No. 4, pages 305-31
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- acute toxicity: inhalation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Investigation of the respiratory effects of sulphuric acid mist inhalation
- GLP compliance:
- no
- Remarks:
- : not applicable
Test material
- Reference substance name:
- Sulphuric acid
- EC Number:
- 231-639-5
- EC Name:
- Sulphuric acid
- Cas Number:
- 7664-93-9
- Molecular formula:
- H2O4S
- IUPAC Name:
- sulfuric acid
- Details on test material:
- Sulphuric acid mist
Constituent 1
Method
- Subjects:
- Male (unspecified number)
- Route of exposure:
- inhalation
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
Results and discussion
- Results of examinations:
- Lung retention of sulfuric-acid averaged 77 percent. Exposures to the lower concentrations of mist caused more shallow and more rapid breathing. The period of expiration was prolonged, averaging 69.3 percent of the breathing cycle versus 59.6 percent of the cycle when the subjects breathed air. At sulfuric-acid concentrations of 5mg/m3, the effects of the mist on respiration were more varied. The major response was a decrease in minute volume.
Any other information on results incl. tables
Lung retention of sulfuric-acid averaged 77 percent. Exposures to the lower concentrations of mist caused more shallow and more rapid breathing. The period of expiration was prolonged, averaging 69.3 percent of the breathing cycle versus 59.6 percent of the cycle when the subjects breathed air. At sulfuric-acid concentrations of 5mg/m3, the effects of the mist on respiration were more varied. The major response was a decrease in minute volume.
Applicant's summary and conclusion
- Conclusions:
- The authors note that sulfuric-acid mists having concentrations below 3mg/m3 are not normally detectable. They conclude that respiratory changes induced by inhaling sulfuric-acid mists at concentrations on the order of 0.35mg/m3 are purely reflexive in nature. The more shallow, more rapid breathing may be a reflex protective mechanism to decrease the retention of acid mist particles.
- Executive summary:
The effects of inhaling sulfuric acid mist were studied in humans. An unspecified number of normal male subjects inhaled sulfuric-acid aerosols at concentrations ranging from 0.35 to 5 milligrams per cubic meter (mg/m3). The subjects were at rest during the exposures and breathed through a face mask. Exposure times ranged from 5 to 15 minutes. Lung retention of sulfuric-acid was determined. The effect of the acid mist on respiration was measured by means of a pneumotachograph. Lung retention of sulfuric-acid averaged 77 percent. Exposures to the lower concentrations of mist caused more shallow and more rapid breathing. The period of expiration was prolonged, averaging 69.3 percent of the breathing cycle versus 59.6 percent of the cycle when the subjects breathed air. At sulfuric-acid concentrations of 5mg/m3, the effects of the mist on respiration were more varied. The major response was a decrease in minute volume. The authors note that sulfuric-acid mists having concentrations below 3mg/m3 are not normally detectable. They conclude that respiratory changes induced by inhaling sulfuric-acid mists at concentrations on the order of 0.35mg/m3 are purely reflexive in nature. The more shallow, more rapid breathing may be a reflex protective mechanism to decrease the retention of acid mist particles.
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