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EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable with restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminum chloride, basic
- EC Number:
- 215-477-2
- EC Name:
- Aluminum chloride, basic
- Cas Number:
- 1327-41-9
- IUPAC Name:
- aluminum trichloride
- Reference substance name:
- Aluminium chlorohydrate
- IUPAC Name:
- Aluminium chlorohydrate
- Details on test material:
- -Name of test material : Aluminium chlorohydrate
-EC name: dialuminium chloride pentahydroxide
- CAS mumber: 12042-91-0
- EC number: 234-933-1
- Molecular formula : Al2Cl(OH)5
- Molecular weight : 174.452776 g/mol
- Smiles notation – Al]([Al](O)(O)Cl)(O)(O)O
- InChI notation- 1/2Al.ClH.5H2O/h;;1H;5*1H2/q2*+3;;;;;;/p-6/rAl2ClH5O5/c3-1(4,5)2(6,7)8/h4-8H
- Structural formula attached as image file : see Fig.2
- Substance type:inorganic
- Physical state: solid
- Density: 1,35g/cm3
- Melting point: >100 °C
- Boiling point: 110-115 °C
- Solubility in water: 500 g/l at 20 o C
Constituent 1
Constituent 2
Test animals
- Species:
- hamster
- Strain:
- other: Golden Syrian
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Hamster (Golden Syrian)
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: alchlor (a propylene glycol complex of aluminum chlorhydrate)
- Details on inhalation exposure:
- A 3-day 4 or 6 hr/d exposure to 31 or 33 mg Al/m3 in hamsters
A 3-day 4 or 6 hr/d exposure to 3 or 7 mg Al/m3 in hamsters - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 3 d
- Concentrations:
- A 3-day 4 or 6 hr/d exposure to 31 or 33 mg Al/m3
A 3-day 4 or 6 hr/d exposure to 3 or 7 mg Al/m3 - Control animals:
- yes
- Details on study design:
- Respiratory effects typically associated with inhalation of particulates and lung overload have been observed in animals. The pulmonary toxicity of alchlor (a propylene glycol complex of aluminum chlorhydrate), a common component of antiperspirants, was examined in hamsters in a series of studies conducted by Drew et al. (1974).
A 3-day exposure to 31 or 33 mg Al/m3 resulted in moderate-to-marked thickening of the alveolar walls due to neutrophil and macrophage infiltration and small granulomatous foci at the bronchioloalveolar junction (a likely site of particulate deposition). A decrease in the severity of the pulmonary effects was observed in animals killed 3, 6, 10, or 27 days after exposure termination.
Similar pulmonary effects were observed in rabbits exposed to 42 mg Al/m3 for 5 days (Drew et al. 1974). Significant increases in absolute lung weights have been observed in hamsters exposed for 3 days to ≥7 mg Al/m3 (no effects were observed at 3 mg Al/m3) and in rabbits exposed to 43 mg Al/m3 for 5 days (no effects were observed in rabbits exposed to 48 or 39 mg Al/m3 for 1 or 4 days, respectively).
Results and discussion
- Preliminary study:
- A 3-day exposure to 31 or 33 mg Al/m3 resulted in moderate-to-marked thickening of the alveolar walls due to neutrophil and macrophage infiltration and small granulomatous foci at the bronchioloalveolar junction (a likely site of particulate deposition). A decrease in the severity of the pulmonary effects was observed in animals killed 3, 6, 10, or 27 days after exposure termination. Significant increases in absolute lung weights have been observed in hamsters exposed for 3 days to ≥7 mg Al/m3 (no effects were observed at 3 mg Al/m3)
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- other: NOAEL
- Effect level:
- 3 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 3 d
- Remarks on result:
- other: (No effects were observed at 3 mg Al/m3)
- Sex:
- male
- Dose descriptor:
- other: LOAEL
- Effect level:
- 7 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 3 d
- Remarks on result:
- other: Increases in absolute lung weights have been observed in hamsters exposed for 3 days to ≥7 mg Al/m3
- Sex:
- male
- Dose descriptor:
- other: LOAEL
- Effect level:
- 10 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 3 d
- Remarks on result:
- other: (approximately 24% increased lung weight)
- Sex:
- male/female
- Dose descriptor:
- other: LOAEL
- Effect level:
- 31 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 3 d
- Remarks on result:
- other: (alveolar wall thickening and increased number of macrophages and heterophils)
- Sex:
- male/female
- Dose descriptor:
- other: LOAEL
- Effect level:
- 43 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 3 d
- Remarks on result:
- other: (alveolar wall thickening, increased number of macrophage; 65% increase in lung weight)
- Mortality:
- No
- Clinical signs:
- other: A 3-day exposure to 31 or 33 mg Al/m3 resulted in moderate-to-marked thickening of the alveolar walls due to neutrophil and macrophage infiltration and small granulomatous foci at the bronchioloalveolar junction (a likely site of particulate deposition).
- Body weight:
- Increases in absolute lung weights (13% increased lung weight) have been observed in hamsters exposed for 3 days to ≥7 mg Al/m3
- Gross pathology:
- A decrease in the severity of the pulmonary effects was observed in animals killed 3, 6, 10, or 27 days after exposure termination.
- Other findings:
- Pulmonary effects were observed in rabbits (New Zealand) exposed to 42 mg Al/m3 for 5 days .
Significant increases in absolute lung weights have been observed in rabbits (New Zealand) exposed to 43 mg Al/m3 for 5 days (no effects were observed in rabbits exposed to 48 or 39 mg Al/m3 for 1 or 4 days, respectively).
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information increases in absolute lung weights (13% increased lung weight) have been observed in hamsters exposed for 3 days to ≥7 mg Al/m3 Criteria used for interpretation of results: EU
- Conclusions:
- increases in absolute lung weights (13% increased lung weight) have been observed in hamsters exposed for 3 days to ≥7 mg Al/m3
- Executive summary:
Respiratory effects typically associated with inhalation of particulates and lung overload have beenobserved in animals. The pulmonary toxicity of alchlor (a propylene glycol complex of aluminumchlorhydrate), a common component of antiperspirants, was examined in hamsters.
A 3-day exposure to 31 or 33 mg Al/m3 resulted in moderate-to-marked thickening of the alveolar walls due to neutrophil and macrophage infiltration and small granulomatous foci at the bronchioloalveolar junction (a likely site of particulate deposition). A decrease in the severity of the pulmonary effects was observed in animals killed 3, 6, 10, or 27 days after exposure termination.
Similar pulmonary effects were observed inrabbitsexposed to 42 mg Al/m3 for 5 days.
Significant increases in absolute lung weights have been observed in hamsters exposed for 3 days to≥7mg Al/m3 (no effects were observed at 3 mg Al/m3) and in rabbits exposed to 43 mg Al/m3 for 5 days (no effects were observed in rabbits exposed to 48 or 39 mg Al/m3 for 1 or 4 days, respectively).
I
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