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Diss Factsheets
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EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Type of information:
- other: handbook data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: handbook with reliable values
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Health effects of alumimium in water
- Author:
- Lenntech organization
- Year:
- 1 993
- Bibliographic source:
- http://www.lenntech.com/periodic/water/aluminium/aluminum-and-water.htm
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of study / information:
- health effects of aluminium in water
Test material
- Reference substance name:
- Aluminium
- EC Number:
- 231-072-3
- EC Name:
- Aluminium
- Cas Number:
- 7429-90-5
- IUPAC Name:
- aluminum
- Test material form:
- solid: compact
Constituent 1
Results and discussion
Any other information on results incl. tables
The total aluminum concentration in the human
body is approximately 9 ppm (dry mass). In some organs, specifically the
spleen, kidneys and lung, concentrations up to 100 ppm (dry mass) may be
present. Daily aluminum intake is approximately 5 mg, of which only a
small fraction is absorbed. This leads to relatively low acute toxicity.
Absorption is about 10 μg per day. These amounts are considered harmless
to humans. Siliconmay
decrease aluminum uptake. However, once the element is taken up in the
body it is not easily removed.
Large aluminum intake may negatively influence health. This was
connected with nerve damage. Particularly people with kidney damage are
susceptible to aluminum toxicity. There is a risk of allergies. Aluminum
is probably mutagenic and carcinogenic. A correlation between aluminum
uptake and an increased number of Alzheimer cases is suspected. However,
this is uncertain because aluminum concentrations always increase with
age. Increased aluminum intake may also cause osteomalacia (vitamin D
and calcium deficits).
Aluminum intake mainly occurs through food and drinking water. The most
recent standards were between 50 and 200 μg/L. Aluminum particles may
cause functional lung disorder.
No known diseases are linked to aluminum shortages.
Applicant's summary and conclusion
- Conclusions:
- The total aluminum concentration in the human body is approximately 9 ppm (dry mass). In some organs, specifically the spleen, kidneys and lung, concentrations up to 100 ppm (dry mass) may be present. Daily aluminum intake is approximately 5 mg, of which only a small fraction is absorbed.
Aluminum intake mainly occurs through food and drinking water. The most recent standards were between 50 and 200 μg/L.
Aluminum particles may cause functional lung disorder.No known diseases are linked to aluminum shortages.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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