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Diss Factsheets
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EC number: 200-449-4 | CAS number: 60-00-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Phototransformation in water
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- To investigate the photodegradation pathway of Fe-EDTA, an aqueous solution of the substance was irradiated with a xenon arc lamp.
The reaction mixture was sampled over a period of 4 days. - GLP compliance:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
Supplier: Eastman Organic Chemicals (unlabelled)
RADIOLABELLING INFORMATION
Supplier: Mallinckrodt Chemical Works (labelled, 1-14C-EDTA)
Specific activity: 9.1 uCi/mg - Radiolabelling:
- yes
- Light source:
- Xenon lamp
- Details on light source:
- Wide spectrum 5500-W Xenon lamp
- Details on test conditions:
- To determine the extent of ferric EDTA removal from the environment by interaction with sunlight - i.e. photodegradation - the behaviour of aqueous solutions of ferric-1-14C-EDTA at pH 4.5, 6.9, and 8.5 under irradiation from a xenon lamp has been studied.
- Initial conc. measured:
- 0.002 mol/L
- % Degr.:
- 100
- Sampling time:
- 24 h
- Test condition:
- Direct photolysis
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer reviewed publication
- Study type:
- not specified
- Principles of method if other than guideline:
- EDTA was disolved in natural lake water and photodegradation over a period of time was determined.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source of test substance: Merck KGaA, Germany
- Test substance prepared in situ by adding FeCl3 to EDTA-Na2H2 - Radiolabelling:
- not specified
- Analytical method:
- high-performance liquid chromatography
- Details on sampling:
- Exposure to Sunlight: Sampling volume was 10 mL and samples were taken first at the beginning, second after two weeks and thereafter samples were taken once a week.
Laboratory conditions: Sampling volume was 7 mL, further data are not available - Buffers:
- no data availble
- Light source:
- Xenon lamp
- Light spectrum: wavelength in nm:
- >= 315 - <= 400
- Details on light source:
- laboratory condition: two black lamps (Sylvania F40W/BL, black light 350), yielding 4.8 mW/cm2 at a distance of 100 mm.
direct sunlight: The average intensity of solar radiation at the range of 290-385 was 0.9 mW/cm2 in June, 0.92 mW/cm2 in July, 0.55 mW/cm2 in August and 0.30 mW/cm2 in September. - Details on test conditions:
- laboratory conditions: Test solutionsin 500 mL glass bowls were placed on magnetic stirrers for mixing. Starting concentration of EDTA was 0.13 mM in destilled and in lake water. The complexation by FeCl3 reduced pH from 6.5 to 3.1 in both media. Therefore, one set was carried out where the pH was adjusted to 6.5 using NaOH.
Exposure to sunlight: Four 100 L aquariums were used and each held 64 L of the test solution (destilled water in the dark, destilled water in the sunlight, lake water in the dark, lake water in the sunlight). Concentration of EDTA was 0.13 mM. Th experiment lasted from June to September. - Duration:
- 14 wk
- Initial conc. measured:
- 0.13 mmol/L
- Reference substance:
- not specified
- Dark controls:
- yes
- Computational methods:
- The rate of photodegradation of Fe(III)-EDTA seemed to follow first-order kinetics.
- Preliminary study:
- no data available
- % Degr.:
- 50
- Sampling time:
- 56.8 d
- Test condition:
- laboratory (lake water)
- % Degr.:
- 50
- Sampling time:
- 45 d
- Test condition:
- laboratory (destilled water)
- % Degr.:
- 74
- Sampling time:
- 50 d
- Test condition:
- Eposure to sunlight
- Predicted environmental photolytic half-life:
- < 50 d without pH adjustment, exposed to direct sunlight.
- Transformation products:
- not specified
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 0.13 mM Na2-EDTA did entirely disappear during 50 days from destilled water, wheras 74 % of NA2-EDTA degraded in lake water during this period of time.
- Endpoint:
- phototransformation in water
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- % Degr.:
- 70
- Sampling time:
- 50 d
- Test condition:
- Exposure to sunlight
Referenceopen allclose all
Carbon dioxide, formaldahyde, N-carboxy-methyl-N,N'-ethylenediglycine (ED3A), N,N'ethylenediglycine (EDDA-N,N'), iminodiacetic acid (IMDA), N-carboxymethyl-N-aminoethyleneglycine (EDDA-N,N), N-aminoethyleneglycine (EDMA), and glycine have been identified as the major photodegradation products. No nitrilotriacetic acid (NTA) was detected during photodegradation.
The rate of photodegradation was pH dependent, being most rapid at pH 4.5. At a light intensity of 4000-ft candles and an initial concentration of 0.0016 M Fe(III)-EDTA removal was complete after 24 h of irradiation at either pH 4.5 or pH 6.9 and after 32 h at pH 8.5.
Description of key information
Key value for chemical safety assessment
Additional information
As phototransformation in water is not a standard information requirement according to Regulation (EC) No. 1907/2006 and there is no indication from the Chemical Safety Assessment according to Annex I on the need to investigate further the fate and behavior of the substance (Annex X requirement), no further testing is considered necessary. Available supporting data for subcategory 1 members indicate that some EDTA species, especially iron complexes, are to a certain degree photolysable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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