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EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
- Acute oral toxicity:The LD50 value from 4618 mg/kg bw to 6200 mg/kg bw in mouse were determined for Aluminium sulphate. This show that Aluminium sulphate has of relatively low acute toxicity of acute oral toxicity. The acute oral median lethal dose to rats of Aluminum sulphate was found to be greater than 5000 mg/kg bodyweight for males and females.
-Acute Dermal Toxicity: An LD50 value of > 1167.5 mg/kg was obtained. No epidermal and pathological changes and dermal reactions were observed with aluminium sulphate treatment up to 233.5 mg/kg bw. This show that Aluminium sulphate is not classified for acute Dermal toxicity .
- Acute inhalation toxicity :Based on the results of thе study (Thomson SM,. 1986), the LC50 for Acute inhalation toxicity of Aluminium sulphate obtained was >50 mg/m³ air .
It is concluded that the substance Aluminium sulphate does meet the criteria to be classified for human health hazards for acute oral, dermal and inhalation effects.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliable without restrictions. Well-presented study, with relevant measurement of chemical concentrations
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Exposure Duration Frequency:The test item was administered in a single dose by gavage and intraperitoneally
- No. of animals per sex per dose:
- 20
- Control animals:
- yes
- Details on study design:
- Four aluminum compounds--nitrate, chloride, sulphate and bromide--were administered orally and intraperitoneally to rats and mice. The LD50-values (14 days) were determined. The majority of deaths occurring during the first four days.
- Preliminary study:
- Four aluminum compounds--nitrate, chloride, sulphate and bromide--were administered orally and intraperitoneally to rats and mice. The LD50-values (14 days) were determined. The majority of deaths occurring during the first four days.
The clinical and physical signs appearing after intoxication include among other lethargy, decreased locomotor activity, piloerection, weight loss and perorbital bleeding. Aluminum concentrations were highest in liver and spleen. No histopathological lesions could be observed.
According to an acute oral toxicity test conducted with aluminium sulphate it can be stated that the substances shows low orally toxic characteristic.The oral LD50 in Mouse (Swiss) was determined to be above 4618 mg/kg body weight or above 730 mg Al/kg bw.
The intraperitoneally LD50 in Mouse (Swiss) was determined to be 253 mg/kg bw or 40 mg Al/kg body weight. - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 618 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The intraperitoneally LD50 in Mouse (Swiss) was determined to be 253 mg/kg bw or 40 mg Al/kg body weight.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 253 mg/kg bw
- Based on:
- test mat.
- Remarks:
- intraperitoneally
- Mortality:
- The majority of deaths occurring during the first four days.
- Clinical signs:
- other: The clinical and physical signs appearing after intoxication include among other lethargy, decreased locomotor activity, piloerection, weight loss and perorbital bleeding.
- Gross pathology:
- After 14 days no alterations in liver and renal functions were detected in the animals which received intraperitoneally the LD50-values of aluminum nitrate as a single dose.
- Other findings:
- Aluminum concentrations were highest in liver and spleen. No histopathological lesions could be observed.
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to an acute oral toxicity test conducted with aluminium sulphate it can be stated that the substances shows low orally toxic characteristic.The oral LD50 in Mouse (Swiss) was determined to be above 4618 mg/kg body weight or above 730 mg Al/kg bw.
The intraperitoneally LD50 in Mouse (Swiss) was determined to be 253 mg/kg bw or 40 mg Al/kg body weight. - Executive summary:
Four aluminum compounds--nitrate, chloride, sulphate and bromide--were administered orally and intraperitoneally to rats and mice. The LD50-values (14 days) were determined. The majority of deaths occurring during the first four days.
The clinical and physical signs appearing after intoxication include among other lethargy, decreased locomotor activity, piloerection, weight loss and perorbital bleeding.
After 14 days no alterations in liver and renal functions were detected in the animals which received intraperitoneally the LD50-values of aluminum nitrate as a single dose. Aluminum concentrations were highest in liver and spleen. No histopathological lesions could be observed. To compare the efficacies of nine chelating agents on the toxicity of aluminum in mice, the therapeutic index and the therapeutic effectiveness of each chelating agent have been calculated. Malic, succinic, oxalic and malonic acids showed the best results with malic and succinic acids being the most effective. Deferoxamine mesylate (DFOA), sodium salicylate, L-cysteine and citric acid were not so effective as antidotes for acute aluminum toxicity. Aurin tricarboxylic acid (ATCA) should not be used due to its high toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 618 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliable without restrictions. Well-presented study, with relevant measurement of chemical concentrations
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: lavage fluid
- Details on inhalation exposure:
- Groups of male, Fischer 344 rats were exposed 4 h to one of five dosage levels of aluminum (1000, 200, 100, 50, 10 mg m-3).
At 24 h, 14 days and 3 months post-exposure (PE), rats were evaluated for physiological and histological alterations to correlate with enzymatic and cytological profiles of lavage fluid.
At 24 h PE, there were dose-related increases in lactate dehydrogenase and protein in lavage fluid of the brass exposed rats, acute inflammatory response in terminal airways, increases in macrophages and neutrophils, and increased pulmonary resistance. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 5 d
- Concentrations:
- aluminum (1000, 200, 100, 50, 10 mg/ m3).
- No. of animals per sex per dose:
- Groups of male, Fischer 344 rats
- Control animals:
- yes
- Details on study design:
- Bronchopulmonary lavage has been used as a rapid screening test for acute lung injury from many pneumotoxic chemicals.
We demonstrated the efficacy of lavage fluid analysis for detection of acute pulmonary damage from inhaled metal dusts.
Groups of male, Fischer 344 rats were exposed 4 h to one of five dosage levels of aluminum (1000, 200, 100, 50, 10 mg m-3).
At 24 h, 14 days and 3 months post-exposure (PE), rats were evaluated for physiological and histological alterations to correlate with enzymatic and cytological profiles of lavage fluid.
At 24 h PE, there were dose-related increases in lactate dehydrogenase and protein in lavage fluid of the brass exposed rats, acute inflammatory response in terminal airways, increases in macrophages and neutrophils, and increased pulmonary resistance.
All reactions were resolved by 14 days PE. In contrast, aluminum powder produced no alteration in pulmonary function, but elicited persistent changes in enzymatic and cytological lavage fluid parameters with multifocal microgranulomas in lungs and hilar lymph nodes. Bronchopulmonary lavage analysis was useful as an indicator of inhalation hazards of brass and aluminum powders. - Preliminary study:
- In rats exposed to aluminum flakes for 5 days, there were alterations in the cytological (increase in the number of polymorphonuclear neutrophils [PMNs]) and enzymatic (increased activity of alkaline phosphatase and lactate dehydrogenase) content of the lavage fluid at ≥50mg Al/m3 and multifocal microgranulomas in the lungs and hilar lymph nodes at ≥200 mg Al/m3 The enzymatic changes in the lavage fluid probably resulted from the presence of PMNs, increased phagocytosis of alveolar macrophages, and Type II cell hyperplasia.
- Sex:
- male
- Dose descriptor:
- other: NOAEL
- Effect level:
- 10 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 5 d
- Remarks on result:
- other: no effect observed
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 50 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 5 d
- Remarks on result:
- other: increased lactate dehydrogenase, glucose- 6-phosphate dehydrogenase, and alkaline phosphatase activity in lavage fluid
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 200 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 5 d
- Remarks on result:
- other: multifocal microgranulomas in lungs
- Mortality:
- no
- Clinical signs:
- other: At 24 h, 14 days and 3 months post-exposure (PE), rats were evaluated for physiological and histological alterations to correlate with enzymatic and cytological profiles of lavage fluid. At 24 h PE, there were dose-related increases in lactate dehydrogen
- Body weight:
- no
- Gross pathology:
- multifocal microgranulomas in lungs at 200 mg/m3 air
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In rats exposed to aluminum suifate flakes for 5 days, there were alterations in the cytological (increase in the number of polymorphonuclear neutrophils [PMNs]) and enzymatic (increased activity of alkaline phosphatase and lactate dehydrogenase) content of the lavage fluid at ≥50mg Al/m3 and multifocal microgranulomas in the lungs and hilar lymph nodes at ≥200 mg Al/m3 The enzymatic changes in the lavage fluid probably resulted from the presence of PMNs, increased phagocytosis of alveolar macrophages, and Type II cell hyperplasia.
- Executive summary:
Bronchopulmonary lavage has been used as a rapid screening test for acute lung injury from many pneumotoxic chemicals. We demonstrated the efficacy of lavage fluid analysis for detection of acute pulmonary damage from inhaled metal dusts. Groups of male, Fischer 344 rats were exposed 4 h to one of five dosage levels of either brass (200, 100, 50, 10, 1 mg m-3) or aluminum (1000, 200, 100, 50, 10 mg m-3). At 24 h, 14 days and 3 months post-exposure (PE), rats were evaluated for physiological and histological alterations to correlate with enzymatic and cytological profiles of lavage fluid. At 24 h PE, there were dose-related increases in lactate dehydrogenase and protein in lavage fluid of the brass exposed rats, acute inflammatory response in terminal airways, increases in macrophages and neutrophils, and increased pulmonary resistance. All reactions were resolved by 14 days PE. In contrast, aluminum powder produced no alteration in pulmonary function, but elicited persistent changes in enzymatic and cytological lavage fluid parameters with multifocal microgranulomas in lungs and hilar lymph nodes. Bronchopulmonary lavage analysis was useful as an indicator of inhalation hazards of brass and aluminum powders.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 50 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliable without restrictions. Guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Groups of 5 mice, 3 rabbits and 2 pigs were treated daily for 5 consecutive days with applications of 10 % w/v aluminium chloride, aluminium nitrate, aluminium chlorhydrate, aluminium sulphate, aluminium hydroxide (the pH of the solution was highest at 7.2 among these chemical species of Al tested) or basic aluminium acetate.
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Skin damage has been observed in female TF1 Carworth mice, New Zealand rabbits, and Large White pigs following the application of 10% aluminum chloride (0.005–0.1 g Al) or aluminum nitrate (0.006– 0.013 g Al) for 5 days; but not from aluminum sulfate, hydroxide, acetate, or chlorhydrate (Lansdown 1973). The damage consisted of hyperplasia, microabscess formation, dermal inflammatory cell infiltration, and occasional ulceration.
These results suggest that the development of adverse dermal effects from exposure to aluminum depends upon its chemical form. - Duration of exposure:
- 5 days
- Doses:
- 233.5 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
- Details on study design:
- Skin damage has been observed in female TF1 Carworth mice, New Zealand rabbits, and Large White pigs following the application of 10% aluminum chloride (0.005–0.1 g Al) or aluminum nitrate (0.006– 0.013 g Al) for 5 days; but not from aluminum sulfate, hydroxide, acetate, or chlorhydrate (Lansdown 1973). The damage consisted of hyperplasia, microabscess formation, dermal inflammatory cell infiltration, and occasional ulceration.
These results suggest that the development of adverse dermal effects from exposure to aluminum depends upon its chemical form. - Preliminary study:
- The responses of mouse, rabbit and pig skin to topically applied solutions of six aluminium salts (aluminium chloride, aluminium nitrate, aluminium sulphate, aluminium hydroxide, aluminium acetate and aluminium chlorhydrate) have been studied in relation to their pH and the deposition of aluminium in the stratum corneum.
Epidermal changes consisting of hyperplasia, microabscess formation, dermal inflammatory cell infiltration and occasionally ulceration were evident in all three species treated with aluminium chloride (10%) and nitrate (10%), but not with aluminium sulphate (10%), hydroxide (10%), acetate (10%) or chlorhydrate (10 and 25%). - Sex:
- female
- Dose descriptor:
- other: NOAEL
- Effect level:
- > 233.5 mg/kg bw
- Based on:
- test mat.
- Remarks:
- The application of 10% aluminum sulphate (0.1 g Al) is equivalent to 100 mgAl/l or 633 mg/l aluminium sulphate. For conversion in mg/kg we have divided to the density of aluminum sulphate (2.71) 633/2.71=233.5 mg/kg
- Remarks on result:
- other: No epidermal and pathological changes and dermal reactions were observed with aluminium sulphate treatment up to 233.5mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 167.5 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- None
- Other findings:
- None
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No epidermal and pathological changes and dermal reactions were observed with aluminium sulphate treatment up to 233.5 mg/kg bw
- Executive summary:
The responses of mouse, rabbit and pig skin to topically applied solutions of six aluminium salts(aluminium chloride,aluminium nitrate,aluminium sulphate,aluminium hydroxide,aluminium acetateand aluminium chlorhydrate)have been studied in relation to their pH and the deposition of aluminium in the stratum corneum.
Epidermal changes consisting of hyperplasia, microabscess formation, dermal inflammatory cell infiltration and occasionally ulceration were evident in all three species treated with aluminium chloride (10%) and nitrate (10%),but not with aluminium sulphate (10%),hydroxide (10%), acetate (10%) or chlorhydrate (10 and 25%).
In skins showing pathological changes, a high degree of aluminium deposition was present in the stratum corneum and the keratin was histochemically abnormal. It contained an unusually high concentration of protein-bound sulphydryl groups and phospholipid, and fluoresced differently to normal with the congo red technique.
Although the irritant aluminium solutions were more acid than the non-irritant salts, pH was not considered to be responsible since solutions of hydrochloric acid or Universal buffer having an equivalent pH were of negligible effect.
The results of this study indicate that as a result of an interaction of the aluminium cation with epidermal keratin, the latter becomes denatured and the stratum corneum is made more permeable.
The manifestation of pathological changes is attributed to the penetration of the aluminium salts through the stratum corneum and their toxic effects on the cells of the epiderm
Reference
The comparative irritancy of several aluminium salts was assessed by Lansdown (1973) in three different species. Groups of 5 mice, 3 rabbits and 2 pigs were treated daily for 5 consecutive days with applications of 10 % w/v aluminium chloride, aluminium nitrate, aluminium chlorhydrate, aluminium sulphate, aluminium hydroxide (the pH of the solution was highest at 7.2 among these chemical species of Al tested) or basic aluminium acetate. Twenty-four hr after the final treatment with aluminium hydroxide, signs of erythema, thickening, scaling hyperkeratosis, acanthosis, microabsecesses and the presence of aluminium in keratin were not observed. After single dermal application of aluminium hydroxide (10%) on mouse, rabbit and pig skin no signs of dermal irritation or inflammation were found (Lansdown, 1973).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 167.5 mg/kg bw
Additional information
Oral exposure
In a study of oral and intraperitoneal administration during 14 days, Llobet et al. (1987) estimated the acute oral toxicity of aluminum chloride, nitrate and sulphate in Sprague-Dawley rats and Swiss mice.
The oral LD50 in Mouse (Swiss) was determined to be above 4618 mg/kg body weight or above 730 mg Al/kg bw.
Aluminum chloride and nitrate produced acute toxicities of similar magnitude (LD50of 222 to 370 mg Al/kg) in the mice and rats, whereas the toxicity of aluminum sulphate was considerably lower (LD50> 4618mg/kg in both species).
In an early review an LD50of apparently 6,200 mg /kg bw was reported for Al2(SO4)3 and of 3,850 mg Al/kg bw for Al(Cl)3administered to mice (R. Ondreička, et al. 1966).
Inhalation exposure
Based on the results of thе study (Thomson SM,.1986), the LC50 for Acute inhalation toxicity of Aluminium sulphateobtained was>50mg/m³ air.In rats exposed to aluminum suifate flakes for 5 days, there were alterations in the cytological (increase in the number of polymorphonuclear neutrophils [PMNs]) and enzymatic (increased activity of alkaline phosphatase and lactate dehydrogenase) content of the lavage fluid at ≥50mg Al/m3 and multifocal microgranulomas in the lungs and hilar lymph nodes at ≥200 mg Al/m3
In Golden Syrian hamsters and New Zealand rabbits exposed over a short duration (four to six hours per day for three to five days at levels of 7 to 200 mg/m3) to aluminum chlorohydrate through inhalation, the effects observed are those typically associated with inhalation of particulate matter, including alveolar wall thickening, increased number of macrophages and increased lung weight (ATSDR 2006).
A more detailed discussion of the pulmonary effects in experimental animals of inhalation exposure to aluminum oxide dust and refractory alumina fibres, and aluminum hydroxide is provided by Krewski et al. (2007).
The observed responses to various species of aluminum are described as “typical of foreign body reaction”, including alveolar proteinosis and wall thickening, and some nodule formation.
Dermal exposure
Dermal effects of aluminum compounds (10% w/v chloride, nitrate, chlorohydrate, sulphate, hydroxide) applied to skin of mice, rabbits and pigs over five-day periods (once per day) include epidermal damage, hyperkeratosis, acanthosis and microabscesses (ATSDR 2006; Krewski et al. 2007).
An LD50 value of>1167.5mg/kg was obtained.No epidermal and pathological changes and dermal reactions were observed with aluminium sulphate treatment up to 233.5 mg/kg bw.This show that Aluminium sulphate is not classifiedfor acute Dermal toxicity .
Justification for classification or non-classification
Based on the hazard assessment of aluminium sulphate in section 2.1 and 2.2.in IUCLID 5.4., available data for the substance and following the “Guidance on Information Requirement and Chemical Safety Assessment R.8. Characterisation of dose [concentration]- response for human health” and according to the criteria described in Directive 67/548 and in the CLP Regulation:
Directive 67/548 |
Very Toxic (T+) R28: Very toxic if swallowed R27: Very toxic in contact with skin R26: Very toxic by inhalation R39/26 R39/27 R39/28: Dangerous of very serious irreversible effects Toxic (T): R25: Toxic if swallowed R24: Toxic in contact with skin R23: Toxic by inhalation R39/23 R39/24 R39/25: Danger of very serious irreversible effects Harmful (Xn): R22: Harmful if swallowed R21: Harmful in contact with skin R20: Harmful by inhalation R65: Harmful may cause lung damage if swallowed R68/20 R68/21 R68/22: Possible risk of irreversible effects Other toxicological properties R67: Vapours may cause drowsiness and dizziness |
CLP |
H300 Acute Tox. 2 Fatal if swallowed H310 Acute Tox. 1 Fatal in contact with skin H330 Acute Tox. 2 Fatal if inhaled H370 STOT SE 1 H301 Acute Tox. 3 Toxic if swallowed H311 Acute Tox. 3 Toxic in contact with skin H331 Acute Tox. 3 Toxic if inhaled H370 STOT SE 1 H302 Acute Tox. 4 Harmful if swallowed H312 Acute Tox. 4 Harmful in contact with skin H332 Acute Tox. 4 Harmful if inhaled H304 Asp. Tox. 1 H371 STOT SE 2 (May cause damage to organs (or state all organs affected if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) Other toxicological properties H336 STOT SE 3 May cause drowsiness or dizziness
|
It is concluded that the substance aluminium sulphate does not meet the criteria to be classified for human health hazards for acute effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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