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EC number: 223-445-4 | CAS number: 3896-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
There are no studies profiling the compound with CAS No. 3896-11-5 with respect to its toxicokinetic behaviour.
The test substance has a molecular weight of 315.7973 g/mol. It is a slightly yellow powder at room temperature. It has a very poorly solubility in water (< 1 mg/L at 20°C). The vapour pressure of the test substance is determined to be 0.00000075 Pa at 20°C. A log P0/w is estimated at 5.55.
Absorption
In oral toxicity studies, in which doses from 2000 up to 7750 mg/kg bw were administered by gavage in rats, no peculiarities as in for example, yellowly discoloration of urine and faeces were reported. Death was also absent and registered clinical signs of toxicity mirrored at least in one experiment normal signs that are commonly seen in acute oral toxicity tests i.e. sedation, dyspnoea, curved position and ruffled fur. Results from acute toxicity tests thus give no indications of systemic bioavailability of the test substance via the GIT. However, indirect indications of systemic availability are seen in a 13 week subchronic study in dogs, in which diets containing the test substance at levels of 200, 1000 or 5000 ppm lead to a significant reduction of body weights in females of the highest dose group. After termination of the 13 week treatment, body weights were normalised. In addition, a significant but reversible (4 weeks recovery) increase in liver weights - that however was not accompanied by histological changes - seen in animals of both sexes of the high dose group suggests a functional adaptation of the liver to increased systemic load. A slight increase in relative liver to body weights was also seen in a 90 day study in Wistar rats given the test substance in diet ad libitum at concentrations of 400, 1000, 2500 and 10000 ppm.
In an acute dermal toxicity study in rats (limit dose of 2000 mg/kg bw), no clinical signs of toxicity and no staining of urine or faeces were observed giving no indication of dermal absorption. The test substance does not cause skin irritation, hence enhanced absorption due to damaged skin tissue is not expected. In guinea pigs (GPMT) and mice (LLNA), the potential to cause hypersensitisation after skin contact was absent. In view of these findings coupled with the fact that the test substance has very low water solubility and a log Po/w of 5.55, systemic bioavailability via dermal absorption would not be expected.
No reliable inhalation studies are available. However, given its very low vapour pressure, and low water solubility, systemic availability after exposure to vapours or dust particle of the test substance is expected to be low.
Distribution and accumulation
Due to its high lipophilic character (log Po/w of 5.55), the test substance if systemic available would be expected to distribute into cells with the intracellular concentration probably higher than extracellular concentration particularly in fatty tissues. Furthermore, due to its high lipophilicity, upon systemic availability there may be a potential to accumulate especially if exposure to the test substance should be frequent.
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