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EC number: 262-104-4 | CAS number: 60207-90-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 413 (90-Day (Subchronic) Inhalation Toxicity Study
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole
- EC Number:
- 262-104-4
- EC Name:
- 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole
- Cas Number:
- 60207-90-1
- Molecular formula:
- C15H17Cl2N3O2
- IUPAC Name:
- 1-{[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: RAIf SPF
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- head only
- Vehicle:
- other: Acetone
- Duration of treatment / exposure:
- 6 hours/day
- Frequency of treatment:
- 5 days per week for 13 weeks
Doses / concentrationsopen allclose all
- Dose / conc.:
- 20 mg/m³ air (nominal)
- Remarks:
- 21 mg/m3 air (actual concentration)
- Dose / conc.:
- 80 mg/m³ air (nominal)
- Remarks:
- 85 mg/m3 air (actual concentration)
- Dose / conc.:
- 200 mg/m³ air (nominal)
- Remarks:
- 191 mg/m3 air (actual concentration)
- Control animals:
- yes, sham-exposed
Results and discussion
Effect levels
- Dose descriptor:
- NOEC
- Effect level:
- 20 mg/m³ air (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- body weight and weight gain
- histopathology: non-neoplastic
- Remarks on result:
- other: Equivalent to 21 mg/m3 air (acutal dose received)
Target system / organ toxicity
- Critical effects observed:
- no
Any other information on results incl. tables
Table 1. Summary of study test atmosphere characteristics
Parameter |
|
|
|
|
|
Group |
Negative control |
Vehicle control |
Exposure level |
||
Gravimetric concentration |
0 (air) |
10 mg/m3 |
21±2 mg/m3 |
85±7 mg/m3 |
191±10 mg/m3 |
Particle size distribution |
>80% smaller than 7 µm |
||||
Air flow (m/sec) |
0.4 |
0.41 |
0.4 |
0.4 |
0.41 |
Temperature (°C) |
24.8 |
24.9 |
24.8 |
24.9 |
24.9 |
Humidity (%) |
63.9 |
66.3 |
66.3 |
65.9 |
64.5 |
Oxygen content (%) |
20.3 |
20.4 |
20.4 |
20.3 |
20.2 |
Mortality: There
were no treatment related mortalities.
Clinical observations: No clinical symptoms and no signs of local
and/or systemic toxicity were observed.
Body weight and gain: Slightly lower body weights in the males at
85±7 mg/m3 and females at 21±2 and 191±10 mg/m3 were seen on some
occasions during the treatment period achieving statistical significance
(p≤0.01) when compared with the controls.
Table 2. Intergroup comparison of mean body weight (g)
Study |
|
Males |
Females |
|||||||
Negative |
Vehicle |
Exposure level |
Negative |
Vehicle |
Exposure level |
|||||
0 (air) |
10 |
21±2 |
85±7 |
191±10 |
0 (air) |
10 |
21±2 |
85±7 |
191±10 |
|
1 |
227 |
232 |
222 |
222 |
216 |
186 |
192 |
184 |
191 |
184 |
2 |
259 |
262 |
251 |
249 |
245 |
199 |
205 |
189 |
196 |
193 |
3 |
292 |
293 |
284 |
278 |
279 |
211 |
214 |
200 |
203 |
201 |
4 |
319 |
318 |
309 |
229* |
302 |
222 |
229 |
209* |
212 |
209* |
5 |
319 |
33 |
327 |
319 |
321 |
228 |
236 |
212* |
219 |
215* |
6 |
332 |
335 |
331 |
321 |
328 |
236 |
239 |
219* |
225 |
217* |
7 |
354 |
356 |
349 |
336* |
349 |
240 |
247 |
225* |
229 |
226* |
8 |
371 |
367 |
361 |
347* |
358 |
246 |
249 |
228* |
236 |
227* |
9 |
387 |
390 |
380 |
366* |
379 |
250 |
257 |
232* |
243 |
234* |
10 |
401 |
413 |
396 |
385 |
399 |
254 |
268* |
242 |
251 |
240 |
11 |
417 |
429 |
417 |
401 |
413 |
260 |
273* |
248 |
253 |
246* |
12 |
429 |
434 |
430 |
414 |
427 |
263 |
274 |
249* |
258 |
250 |
13 |
433 |
448 |
446 |
425 |
439 |
265 |
273 |
250* |
258 |
249* |
* Statistically
significant difference from control group mean (p≤0.01).
Food
consumption and utilisation: No
effect on food consumption or food utilisation was noted.
Food consumption and compound intake: The mean food consumption
of all treated male and female rats was comparable to the controls.
Ophthalmoscopic examination: No treatment related effects noted.
Haematology:
There were no differences in
haematological parameters which were considered to be related to
treatment.
Blood clinical chemistry: There were no differences in blood
clinical chemistry parameters which were considered to be related to
treatment.
Sacrifice
and pathology:
Organ weights: Some
organ weight, organ to body weight and organ to brain weight ratios
showed some intra-group variation, but none were considered to be
toxicologically significant.
Macroscopic findings: There were no treatment related macroscopic
abnormalities.
Microscopic findings: There were no treatment related microscopic
abnormalities.
Applicant's summary and conclusion
- Conclusions:
- A NOEC of the test substance for male rats was established at 20 mg/m3 (21 mg/m3 acutal dose received) but not for females because of the body weight differences noted at this exposure level.
- Executive summary:
In this inhalation toxicity study, test substance was administered by aerosol exposure (to the head only) to groups of 20 male and 20 female RAIf SPF rats at dose levels of 0 (air), 10 (acetone, vehicle control), 21±2, 85±7 or 191±10 mg/m3 for 6 hours per day, 5 days per week for a period of 90 days.Test atmospheres were analysed daily for particulate concentration and test substance. Mortality, clinical observations, body weights and food consumption were measured throughout the study. Blood samples were collected from 10 fasted rats per sex per group at 6 and 13 weeks for haematology and clinical chemistry analysis. Brain, heart, liver, lungs and kidneys were weighed. A comprehensive range of organs and tissues from all animals was examined histopathologically.
There were no treatment related mortalities. No clinical symptoms and no signs of local and/or systemic toxicity were observed. No effects on food consumption or food utilisation were noted. Slightly lower body weights in the males at 85±7 mg/m3and in females at 21±2 mg/m3 and 191±10 mg/m3 were seen on some occasions during the treatment period when compared with the controls. The results of the haematological investigation and blood chemistry data were generally unremarkable for both treated rats and controls. There were no treatment related macroscopic or microscopic changes. Some organ weight, organ to body weight and organ to brain weight ratios showed some intra-group variation, but none were considered to be toxicologically significant.A NOEC of test substance technical for male rats was established at 21 mg/m3 but not for females because of the body weight differences noted at this exposure level.
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