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EC number: 240-968-3 | CAS number: 16919-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Publication date - 07 May 1982.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Organisation for Economic Co-operation and Development (1979). OECD Short-term and Lone-term Toxicology’ Groups. Final Report: Acute Dermal Irritation/ Corrosivity. 31 December. p. 35.
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- disodium;hexafluorosilicon(2-)
- Cas Number:
- 16893-85-9
- Molecular formula:
- Na2SiF6
- IUPAC Name:
- disodium;hexafluorosilicon(2-)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The test was carried out on male albino rabbits of the New Zealand strain, weighing about 2.5 kg and supplied by Roucher SA, Couht. The study was conducted in a single group of six rabbits.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 1/24/48/72 h
- Score:
- 0.04
- Remarks on result:
- other: Reversibility not specified
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- Only PDI available.
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual scores not available.
- Remarks:
- Only PDI available.
- Irritation parameter:
- edema score
- Basis:
- other:
- Remarks:
- Only PDI available
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual scores not available.
- Remarks:
- Only PDI available.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Sodium fluorosilicate was concluded to be non irritant to the skin.
- Executive summary:
The skin irritation potential of sodium fluorosilicate was evaluated by Guillot et al, 1982. The test was carried out on male albino rabbits of the New Zealand strain, weighing about 2.5 kg and supplied by Roucher SA, Couht. The study was conducted in a single group of six rabbits. Each rabbit was clipped over the back and flanks with a fine-toothed electric clipper (Aesculap Type V 42 947).
0.5 g was applied on the shaved skin and the treated skin was covered in each case with a four-layered sterile absorbent-gauze square (2 x 2 cm), which was moistened with 0.5 ml water. The test material and gauze pads were kept in contact with the skin by a patch (Neodermotest Rot SA, Paris) consisting of an occlusive central disc (22 mm in diameter) surrounded by an adhesive hypoallergenit perforated plaster (10 mm wide). Finally an adhesive tape (6 cm wide) was wound round the animal, without restricting respiratory and abdominal movements, to complete the holding of the patches, and the rabbit was placed in a restraining device for at least 4 h. Macroscopic observations were recorded at 1, 24, 48 and 72 h for both after patch removal. Each treated area was scored for erythema and oedema using a numerical system (0-4 in each case according to severity) based on that described by Draize, Woodard & Calvery (1948). The scores obtained for erythema and oedema at both of the treated sites in all six animals at the two or more reading times were totaled. The sum obtained was then divided by the total number of readings to provide a mean score (never greater than 8) termed the primary irritation index (PCI). The following scale was used to interpret the results:
PCI below 0.5: non-irritant; 0.5-3: slightly irritant; 3-5: moderately irritant; 5-8: severely irritant
The primary cutaneous irritation index obtained in this study was 0.04, hence the substance was concluded to be non-irritant to the skin.
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