Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-968-3 | CAS number: 16919-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The LD50 of ammonium hexafluorosilicate was considered to be 70 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study completion date - 01 January 1988.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 70 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Details not available
- Clinical signs:
- other: - PERIPHERAL NERVE AND SENSATION: Flaccid paralysis without anesthesia (usually neuromuscular blockage); - BEHAVIORAL: Ataxia; - BEHAVIORAL: Muscle contraction or spasticity
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD50 for sodium hexafluorosilicate was found to be 70 mg/kg bw.
- Executive summary:
The acute oral toxicity of sodium hexafluorosilicate was evaluated in this study conducted with mice. The test substance was administered via drinking water. Flaccid paralysis resulting from neuromuscular blockage, ataxia and muscle contraction or spasticity were the clinical signs observed in this study. The study concluded that the LD50 for sodium hexafluorosilicate was 70 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 70 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The hexafluorosilicates disassociate into hexafluorosilicate ion and corresponding cation when dissolved in water. Further the hexafluorosilicate ion dissociates to fluoride ions and hydrated silica and the disassociation is essentially complete at the pH of drinking water (6.5–8.5) (NTP, 2001; NICNAS, 2017). The monovalent cations and hydrated silica are known to have low toxicity. Hence, the fluoride ion is considered to be the driver of toxicity. Taking this into consideration, in addition to limited details available about acute toxicity of ammonium hexafluorosilicate or sodium hexafluorosilicate, data available for sodium fluoride (CAS No. 7681-49-4) has been used for in this summary, to support the conclusion. Currently, no study is available on Ammonium hexafluorosilicate. However, a similar substance, Sodium hexafluorosilicate was evaluated in this study conducted with mice. The test substance was administered via drinking water. Flaccid paralysis resulting from neuromuscular blockage, ataxia and muscle contraction or spasticity were the clinical signs observed in this study. The study concluded that the LD50 for sodium hexafluorosilicate was 70 mg/kg bw. Further, references discuss the LD50 of sodium hexaflurorosilicate to be 125 mg/kg bw in rats as well as rabbits, though further details about the study conditions are not available (RTECS: sodim hexafluorosilicate, as available on 17 July, 2017). Ammonium hexafluorosilicate has been described to have the LD50 of 100 mg/kg bw (NICNAS, 2017). However, no further details are available. Sodium fluoride has been reported to have LD50 of 31–101 mg fluoride/kg bw in rats, while in mice it was 44.3 and 58 mg fluoride/kg bw (Fluorides: Environmental Health Criteria 227, World Health Organization Geneva, 2002). Hence, the data on sodium fluorides also supports the conclusion that ammonium hexafluorosilicate is highly toxic, and should be classified as acute toxicity category 3 according to the CLP.
Justification for classification or non-classification
Based on the available data, ammonium hexafluorosilicate should be classified as acute toxicity category 3 according to the CLP (Regulation EC No. 1272/2008) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.