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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 264-150-0 | CAS number: 63449-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_classification-and-labelling-and-pbt-assessment.png)
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence(P, vP)
LCCPs are not considered to be readily biodegradable; however, data indicate the potential for biodegradation, especially with acclimated microorganisms. The potential for biodegradation appears to increase with decreasing chlorine content. There is also information to suggest that biodegradation of LCCPs may occur under anaerobic conditions. LCCPs have not be shown to be toxic to microorganisms, so they should not inhibit biodegrading microorganisms.
Half-live estimates are difficult to determine accurately based on the biodegradation data set. Based on the relatively slow degradation rates in studies both the ECB TC NEC PBT Working Group (ECB 2007) and the Environment Agency (UK EA 2009) concluded that LCCPs may meet the criteria for P or vP.
Bioaccumulation (B, vB)
Given the very low water solubility of LCCPs, it is difficult to obtain reliable measured bioaccumulation data. The estimated BCFs in fish for the LCCP are as follows (method taken the well accepted method from the EU Technical Guidance Document parabolic equation, application for substances with log Kow >6 and molecular weight < 700 g/mol: log BCF = -0.2 x(log Kow)2+ (2.74 x log Kow – 4.72); (Veith et al, 1979):
C18‑20liquid LCCP BCF = 1,096 L/kg
C20-30liquid LCCP BCF = 192 L/kg
C20-30solid LCCP BCF <1 L/kg
There is evidence from feeding studies that LCCPs can be taken up via the diet, but in all cases the concentrations reached in the animals were less than those in the diet. This indicates that although uptake of the substance can occur via the food, the levels should not increase through the food chain (UK EA 2009).
Based on the estimates of BCF it is concluded that LCCPs are unlikely to meet the B or vB (very bioaccumulative) EU criteria (ECB 2007, OECD 2009, UK EA, 2009).
Toxicity (T)
LCCP have a low order of toxicity to both mammalian and environmental species. They are not classified as dangerous to either human health or the environment.
There is long-term animal toxicity data for LCCPs which indicates that LCCP are not CMRs or meet any of the other criteria for healthclassifications (e.g., T, R48, or Xn, R48) according to Directive 67/548/EEC.
There is a relatively large amount of aquatic toxicity data available for LCCPs. LCCPs havevery low water solubility andshow no toxicity at concentrations at or below their water solubility. (OECD 2009).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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