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EC number: 202-486-1 | CAS number: 96-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: - followed recognized toxicology testing procedures - GLP compliant - study results copied without further assessment from the SIDS dossier
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
- Reference Type:
- secondary source
- Title:
- SIDS INITIAL ASSESSMENT REPORT For SIAM 18 - 1,2,3-Trichloropropane
- Author:
- OECD
- Year:
- 2 004
- Bibliographic source:
- Published OECD SIDS initial assessments of HPV chemicals: http://www.oecd.org/document/63/0,3343,en_2649_34379_1897983_1_1_1_1,00.html
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: NAS Publication 1138 dtd 1977); Thompson-Weil Moving Average Method (1947)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2,3-trichloropropane
- EC Number:
- 202-486-1
- EC Name:
- 1,2,3-trichloropropane
- Cas Number:
- 96-18-4
- Molecular formula:
- C3H5Cl3
- IUPAC Name:
- 1,2,3-trichloropropane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: males weighing 205-275 grams; females weighing 180-240 grams when tested
- Fasting period before study: 16 - 24 h
- Housing: 1 per cage
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reported
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- no vehicle used
MAXIMUM DOSE VOLUME APPLIED: 1.8 ml/kg
DOSAGE PREPARATION (if unusual): no dosage preparation, treatment with undiluted test item via gavage
- Doses:
- Seven dose levels: 0.056, 0.1, 0.18, 0.32, 0.56, 1.0, and 1.8 ml/kg (equivalent to: 78.8, 140, 253, 450, 788, 1400 and 2530 mg/kg);
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: pre and post dosing and weekly thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: not reported - Statistics:
- Values determined by method of Thompson and Weil, where appropriate, or by Litchield and Wilcoxon and 95% confidence limits provided.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 120 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 188 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 152 mg/kg bw
- Mortality:
- males are generally more susceptible to 1,2,3-trichloropropane toxicity than females, see table 1 for details
- Clinical signs:
- other: The most prevalent in-life observations included: piloerection, polyuria, diarrhea, lacrimation, salivation, decreased activity, constricted pupils, corneal opacity, ptosis, nasal discharge, ataxia, lethargy, and difficult and labored breathing.
- Gross pathology:
- Significant gross necropsy findings included: discoloration of the stomach/intestines/urinary bladder/ liver and kidneys; testes drawn into abdominal cavity; distended cecum, prolapsed penis, black patches on liver, red patches on cardiac region and pyloric regions of stomach
Any other information on results incl. tables
- Table 1: Number of animals dead
Dose |
Mortality (# dead/total) |
Time range of deaths (hours) |
||
Male |
Female |
Combined |
||
Control |
- |
- |
- |
|
0.056 |
0/5 |
0/5 |
0/10 |
|
0.100 |
4/5 |
1/5 |
5/10 |
d 1 to d 10 |
0.180 |
5/5 |
- |
- |
d 1 to d 2 |
0.320 |
5/5 |
- |
- |
d 1 to d 2 |
0.560 |
5/5 |
5/5 |
10/10 |
d 1 to d 2 |
1.00 |
5/5 |
5/5 |
10/10 |
d 1 |
1.80 |
5/5 |
- |
- |
d 1 |
- Table 2: Average body weights and body weight gains before and after single oral treatment
Dose rate (ppm) |
Body Weights (g) |
Total Weight Gain |
||||
day ‑1 |
day 1 |
day7 |
Day 14 |
g |
% of lowest dose |
|
Male |
||||||
0.056 |
280 ± 16.6 |
257 ± 16.0 |
302 ± 25.4 |
328 ± 32.7 |
48 ± 21.7 |
100 |
0.100 |
261 ± 18.5 |
240 ± 20.9 |
200 ± 77.8 |
295 |
n/a |
- |
0.180 |
254 ± 17.1 |
231 ± 13.9 |
- |
- |
- |
- |
0.320 |
255 ± 15.0 |
237 ± 14.4 |
- |
- |
- |
- |
0.560 |
253 ± 14.8 |
229 ± 13.4 |
- |
- |
- |
- |
1.00 |
249 ± 9.6 |
228 ± 7.6 |
- |
- |
- |
- |
1.80 |
252 ± 21.7 |
249 ± 45.7 |
- |
- |
- |
- |
Female |
||||||
0.056 |
226 ± 12.4 |
209 ± 13.9 |
231 ± 201 |
247 ± 18.2 |
21 ± 7.4 |
100 |
0.100 |
215 ± 11.7 |
193 ± 9.1 |
211 ± 9.5 |
230 ± 16.6 |
15 ± 22.6 |
71.4 |
0.560 |
215 ± 25 |
196 ± 24.3 |
- |
- |
- |
- |
1.00 |
216 ± 8.2 |
200 ± 7.1 |
- |
- |
- |
- |
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral toxicity of 1,2,3-trichloropropane was tested using a recognized scientific procedure and followed recognized GLP procedures.
The following threshold values were determined:
LD50 (oral, rat, male) = 120 mg/Kg bw
LD50 (oral, rat, female) = 188 mg/Kg bw
LD50 (oral, rat, combined) = 152 mg/Kg bw - Executive summary:
In the present study (Shell Development Company,1980) male and female Sprague-Dawley rats were treated once orally with undiluted 1,2,3 -trichloropropane via gavage and analysed for mortality, body weight development and clinical signs following generally the OECD TG 401 in compliance with GLP.
The following threshold values were determined:
LD50 (oral, rat, male) = 120 mg/Kg bw
LD50 (oral, rat, female) = 188 mg/Kg bw
LD50 (oral, rat, combined) = 152 mg/Kg bw
Based on this results 1,2,3 -trichloropropane is classified as Category III (Toxic if swallowed (oral)) according to CLP (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) as implementation of UN-GHS in the EU.
Thirty-five male and 35 female Sprague-Dawley rats were divided equally into 7 dosage groups (0.056, 0.1, 0.18, 0.32, 0.56, 1.0, and 1.8 ml/kg,equivalent to: 78.8, 140, 253, 450, 788, 1400 and 2530 mg/kg) and administered a single dose of the test material via gavage. Animals were fasted overnight for 16-24 hours (except for water). Animals observed for 14 days for mortality, pharmacologic and/or toxicologic effects hourly for the first 6 hours and at least twice daily for 14 days. Individual body weights were recorded prior to fasting, at time of dosing and on day 7 and 14, or at time of discovery of death. All animals were subjected to gross necropsy, either at termination or time of discovery of death.
The most prevalent in-life observations included: piloerection, polyuria, diarrhea, lacrimation, salivation, decreased activity, constricted pupils, corneal opacity, ptosis, nasal discharge, ataxia, lethargy, and difficult and labored breathing. Significant gross necropsy findings included: discoloration of the stomach/intestines/urinary bladder/ liver and kidneys; testes drawn into abdominal cavity; distended cecum, prolapsed penis, black patches on liver, red patches on cardiac region and pyloric regions of stomach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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