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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-486-1 | CAS number: 96-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 7.964 µg/m³
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 1 674
- Dose descriptor starting point:
- T25
- Value:
- 5.12 mg/kg bw/day
- Modified dose descriptor starting point:
- T25
- Value:
- 13.33 mg/m³
- AF for dose response relationship:
- 25
- Justification:
- AF for T25
- AF for differences in duration of exposure:
- 0.4
- Justification:
- 1/2.8: for adjustment of 5d/wk to 7d/wk, 48/52 wks, 40/75 yrs
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- included in respiration rate
- AF for other interspecies differences:
- 2.5
- Justification:
- Guidance
- AF for intraspecies differences:
- 5
- Justification:
- Guidance
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 10
- Justification:
- Nature of carcinogenic process
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.2 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 938
- Modified dose descriptor starting point:
- other: LC50
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 1.146 µg/kg bw/day
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 4 464
- Dose descriptor starting point:
- T25
- Value:
- 5.12 mg/kg bw/day
- Modified dose descriptor starting point:
- T25
- Value:
- 5.12 mg/kg bw/day
- AF for dose response relationship:
- 25
- Justification:
- AF for T25
- AF for differences in duration of exposure:
- 0.357
- Justification:
- 1/2.8, for adjustment of 7d/wk to 5d/wk, 48/52 wks, 40/75 yrs
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default
- AF for other interspecies differences:
- 5
- Justification:
- default
- AF for intraspecies differences:
- 2.5
- Justification:
- default
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 10
- Justification:
- nature of carcinogenic process
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.6 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 655
- Modified dose descriptor starting point:
- other: LD50
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - workers
1,2,3 -trichloropropane is deemed a potentiallyg enotoxic carcinogen (in vivo genotoxicity in question). Therefore the threshold values for acute toxicity were derived as DNELs assuming that a single exposure is not sufficient to cause a significant risk for carcinogenicity, while for long-term exposure DMELs were calculated based on the T25 value derived from the 2 year gavage carcinogenicity study by NTP (National Toxicology Program (1993) / Rats)
1,2,3-trichloropropane is handled as transported intermediate only, under strictly controlled conditions. Therefore under normal conditions repeated exposure is only expected via the inhalative route on a very low level. Only in cases of accidents, there might be acute exposure to higher amounts of the substance via the skin or the inhalation route.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 0.711 µg/m³
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 6 250
- Dose descriptor starting point:
- T25
- Value:
- 5.12 mg/kg bw/day
- Modified dose descriptor starting point:
- T25
- Value:
- 4.44 mg/m³
- AF for dose response relationship:
- 25
- Justification:
- AF for T25
- AF for differences in duration of exposure:
- 1
- Justification:
- chronic study
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- included in repiratory volume
- AF for other interspecies differences:
- 10
- Justification:
- default
- AF for intraspecies differences:
- 2.5
- Justification:
- default
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 10
- Justification:
- nature of carcinogenic process
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.05 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 1 574
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 0.205 µg/kg bw/day
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25 000
- Dose descriptor starting point:
- T25
- Value:
- 5.12 mg/kg bw/day
- Modified dose descriptor starting point:
- T25
- Value:
- 5.12 mg/kg bw/day
- AF for dose response relationship:
- 25
- Justification:
- AF for T25
- AF for differences in duration of exposure:
- 1
- Justification:
- chronic study
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default
- AF for other interspecies differences:
- 10
- Justification:
- default
- AF for intraspecies differences:
- 2.5
- Justification:
- default
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 10
- Justification:
- nature of carcinogenic process
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.19 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 2 080
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DMEL (Derived Minimum Effect Level)
- Value:
- 0.205 µg/kg bw/day
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25 000
- Dose descriptor starting point:
- T25
- Value:
- 5.12 mg/kg bw/day
- AF for dose response relationship:
- 25
- Justification:
- AF for T25
- AF for differences in duration of exposure:
- 1
- Justification:
- chronic study
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default
- AF for other interspecies differences:
- 10
- Justification:
- default
- AF for intraspecies differences:
- 2.5
- Justification:
- defgault
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 10
- Justification:
- nature of carcinogenic process
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.012 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10 000
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - General Population
1,2,3 -trichloropropane is deemed a potentially genotoxic carcinogen (even though the genotoxicity in vivo is in question). Therefore the threshold values for acute toxicity were derived as DNELs assuming that a single exposure is not sufficient to cause a significant risk for carcinogenicity, while for long-term exposure DMELs were calculated based on the T25 value derived from the 2 year gavage carcinogenicity study by NTP (National Toxicology Program (1993) / Rats)
1,2,3-trichloropropane is handled as transported intermediate only, under strictly controlled conditions. Therefore under normal conditions repeated exposure is only expected via the inhalative route on a very low level. Only in cases of accidents, there might be acute exposure to higher amounts of the substance via the skin or the inhalation route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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