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Diss Factsheets
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EC number: 203-149-1 | CAS number: 103-83-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined; all essential data reported.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The acute toxicity and primary irritancy of N-Benzyl-N,N-Dimethylamine
- Author:
- Ballantyne B, Dodd DE, Nachreiner Dj, Myers RC
- Year:
- 1 985
- Bibliographic source:
- Drug and Chemical Toxicology, 8; 43-56 (1985)
- Reference Type:
- other: Microfiche
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
- Reference Type:
- publication
- Title:
- Comparative acute toxicity and primary irritancy of various classes of amines
- Author:
- Myers R.C. et al.
- Year:
- 1 997
- Bibliographic source:
- Toxic Substance Mechanisms, 16: 151-193 (1997)
Materials and methods
- Principles of method if other than guideline:
- Undiluted test material was administered by gavage, using a ball-ended stainless steel needle attached to a syringe, to groups of 5 male Wistar-derived rats of 90-120 g and 3-4 weeks of age. Animals were observed daily for signs of toxicity over a 14-day postdosing period, at the end they were subjected to gross pathological examination.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzyldimethylamine
- EC Number:
- 203-149-1
- EC Name:
- Benzyldimethylamine
- Cas Number:
- 103-83-3
- Molecular formula:
- C9H13N
- IUPAC Name:
- benzyldimethylamine
- Details on test material:
- Purity: 99.2 %
Density: 890 mg/ml at 25 C
Molecular Weight: 135.23
Boiling Point: 179.6°C
Vapor Pressure: 1.31 Torr at 20°C
1.82 Torr at 25°C
10.00 Torr at 55°C
50.00 Torr at 91°C
Flash Point: 57°C (Cleveland Open Cup)
Solubility: Readily soluble in aqueous acids, methanol, acetone and benzene. Water solubility, 0.12 g/dl.
Specific Gravity: 0.89 (25°C)
Saturated Vapor Concentration: 14430 mg/m³ (25°C)
Conversion Factors: 1 ppm= 5.53 mg/m³ (25°C, 760 Torr)
1 mg/m³= 0.181 ppm (25°C, 760 Torr)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3-4 weeks
- Weight at study initiation: 90-120 g
ENVIRONMENTAL CONDITIONS
- Temperature (°F) 68-80:
- Humidity (%):39-65
- Photoperiod (hrs dark / hrs light):12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Undiluted Tets material was administered by gavage, using a ball-ended stainless steel needle attached to a syringe
- Doses:
- 0.5 , 1.0, 2.0 ml/kg bw = 445, 890, 1780 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Undiluted test material was administered by gavage, using a ball-ended stainless steel needle attached to a syringe, to groups of 5 male Wistar-derived rats of 90-120 g and 3-4 weeks of age. Animals were observed daily for signs of toxicity over a 14-day postdosing period, at the end they were subjected to gross pathological examination.
- Statistics:
- moving average method
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.65 mL/kg bw
- 95% CL:
- 0.48 - 0.88
- Remarks on result:
- other: (approx. 579 mg/kg bw) Signs of toxicity within a few min after dosing. tremor and salivation; deaths occurred within 10 to 90 min after dosing; necropsy: Dead rats: congestion in stomach and intestines, hemorrhages in stomach, Survivors: no findings
- Mortality:
- 0.5 ml/kg bw: 1/5 rat 1.5 h post dosing
1.0 ml/kg bw 5/5 rats 7-20 min post dosing
2.0 ml/kg bw: 5/5 rats 10-20 mi post dosing - Clinical signs:
- other: other: salivation and tremor
- Gross pathology:
- Gross necropsy findings:
Dead animals: congestion in stomach and intestines,hemorrhages in stomach
Survivors: no abnormal findings - Other findings:
- no data
Any other information on results incl. tables
RS-Freetext:
Mortality:
Dose % Time after appl.
low 20 1.5 h
medium 100 7-20 min
high 100 10-20 min
LD50 = 0.65 ml/kg bw (0.48-0.88 ml/kg bw)
= 579 mg/kg bw
Signs of toxicity: Tremors, salivation, death within few minutes to 1.5 h.
Gross necropsy findings:
Dead animals: congestion in stomach and intestines,hemorrhages in stomach
Survivors: no abnormal findings
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
In an acute oral toxicity study undiluted test material was administered by gavage to groups of 5 male Wistar-derived rats of 90-120 g and 3-4 weeks of age. Following doses were tested: 0.5 , 1.0, 2.0 ml/kg bw (445, 890, 1780 mg/kg bw) Animals were observed daily for signs of toxicity over a 14-day postdosing period, at the end they were subjected to gross pathological examination. All animals died at a dose of 2.0 and 1.0 ml/kg bw, but only 1 of 5 at 0.5 ml/kg, indicating a steep slope to the response. Deaths occurred within 10 to 90 minutes after dosing, with the latency increasing as dosage decreased. Signs of toxicity included tremors and salivation which were seen within a few minutes after dosing. Autopsy examination of dead animals showed congestion and hemorrhages of the stomach, and intestinal congestion. Survivors of the 0.5 ml/kg bw group, sacrificed at the end of the 14 -day postdosing observation period, showed no gross abnormalities at autopsy. The LD50 was 0.65 ml/kg bw (resp. 579 mg/kg bw, Ballantyne1985).
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