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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-149-1 | CAS number: 103-83-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: occupational surveillance
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: occupational surveillance reported in brief
Data source
Reference
- Reference Type:
- publication
- Title:
- N,N-Dimethylbenzylamine: Occupational exposure, analysis and biological monitoring
- Author:
- Stahlbom B. et al.
- Year:
- 1 995
- Bibliographic source:
- Int. Arch. Occup. Environ. Health 67: 159-164 (1995)
Materials and methods
- Study type:
- biological exposure monitoring
- Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- DMBA exposure in the air of an epoxy resin production plant was determined and some workers of this plant were examined for urinary DMBA after workshift of 8 hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzyldimethylamine
- EC Number:
- 203-149-1
- EC Name:
- Benzyldimethylamine
- Cas Number:
- 103-83-3
- Molecular formula:
- C9H13N
- IUPAC Name:
- benzyldimethylamine
- Details on test material:
- epoxy resin was mixed with hexahydrophthalic anhydride as a hardener in which DMBA was involved as accelerator (no further data)
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- --The study was carried out in a plant manufacturing electrical capacitors. Epoxy resin was used for electrical insulation. Hexahydrophthalic anhydride as a hardener was mixed with epoxy resin in which DMBA was involved as accelerator. During the process the temperature of the epoxy resin was increased to 90 °C.
--10 healthy male workers were studied. The workers were between 19 and 63 years old and had been employed for a mean of 10 years in the same kind of work: 7/10 were fillers, 2/10 repairers, 1/10 a foreman. There were no restrictions on their diet during the study.
--Exposure of DMBA was measured in the breathing zone to each worker during the full shift (8 h). The air samples were taken during 1 to 3-h periods with personal sampling pumps. A total of 36 breathing zone samples were collected during the shift. Urine specimens were sampled immediately after the workshift. The urine samples were acidified with concentrated hydrochloric acid. DMBA content in the urine was measured before and after reduction of the urine samples Determination of DMBA by gas chromatography.
Results and discussion
- Results:
- In the plant studied, the DMBA exposure ranged from 3 to 48 µg/m³ (mean 18 µg/m³) with a peak concentration
during a single sampling period of 91 µg/m³. The DMBA concentrationin the urine samples were below the detction
limit (0.02 mg/l) of the method used. After reduction of the urine samples the DMBA concentrations ranged from
0.02 mg/l to 0.22 mg/l. There was a significant correlation between the exposure to DMBA and the amount of DMBA
in the urine determined post reduction.
Applicant's summary and conclusion
- Executive summary:
DMBA exposure in the air of an epoxy resin production plant was determined and some workers of this plant were
examined for urinary DMBA after workshift of 8 hours. In the plant studied, the DMBA exposure ranged from
3 to 48 µg/m³ (mean 18 µg/m³) with a peak concentration during a single sampling period of 91 µg/m³. The DMBA
concentrationin the urine samples were below the detection limit (0.02 mg/l) of the method used. After reduction of
the urine samples the DMBA concentrations ranged from 0.02 mg/l to 0.22 mg/l. There was a significant correlation
between the exposure to DMBA and the amount of DMBA in the urine determined post reduction.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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