Registration Dossier
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Diss Factsheets
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EC number: 936-414-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
All relevant and available information on intrinsic properties of MWCNT are cited in chapter 7 of the IUCLID. Although a large number of studies on the toxicity of MWCNTs have recently been published, clear characterization of the test materials including sample preparation which are quite essential for ensuring reproducibility and reliability in the toxicity test using suspension, in vivo and in vitro methods, is often missing. Importantly, modifications of some specific characteristics of the MWCNT tested such as variations in particle size distribution or length might give rise to differences in the toxicological profile.
Toxic effects of different MWCNTs seem to depend on the form (length) and physico-chemical properties (metal content, aggregation/agglomeration, surface chemistry, and functionalisation). Thus for the time being, a case-by-case approach would be appropriate and the hazard assessment for MWCNT meeting the form described in section 4.5 of the IUCLID dossier is based solely on the information collected with this MWCNT. That is the reason why a comprehensive documentation in the IUCLID dossier and the chemical safety report involved automatically is restricted to all available and relevant data on the MWCNT meeting the form described in section 4.5 of the IUCLID dossier. That means on the other hand that the values used for the risk assessment exercise should not be used in general for all MWCNTs or CNTs, as the results obtained with one particular type of MWCNTs may not necessarily be relevant for other CNTs with other dimensions and properties
In addition the information on MWCNT not meeting the form described in section 4.5 of the IUCLID dossier (the differences can be tracked back to the original papers or because in others the characterization of the materials was unclear or inclomplete) is also included in the IUCLID dossier but the entries are restricted to the information on data source to give a quick overview of all available data.
In vitro studies have used a variety of cell types under various experimental conditions. However the toxic responses were not consistently reproduced by different investigators, and may therefore be related to the experimental set up (specifically the cell investigated, MWCNT concentration, or exposure time, and assays used to assess toxicity) used to determine their toxic potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.