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EC number: 253-775-4 | CAS number: 38083-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No study period specified, but the study report was finalized on 1975-01-08.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a method that is largely comparable to the current OECD guideline 401. However, it was not conducted according to the principles of GLP, as GLP had not yet been implemented at the time the study was performed.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The test item was administered orally to groups of 10 male and female Wistar rats at dose levels of 160, 200, 250, 320, 400, 500, 630, 800, and 1000 mg/kg. Toxicity symptoms and mortality rates were recorded for a 14-d observation period. Animals that died were, whenever possible, autopsied and examined for pathological changes. The surviving rats were killed at the end of the trial and also autopsied. Computation of the LD50 values, with a confidence range of p = 0.05 was carried out by means of programmed probit analysis.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Climbazole
- EC Number:
- 253-775-4
- EC Name:
- Climbazole
- Cas Number:
- 38083-17-9
- Molecular formula:
- C15H17ClN2O2
- IUPAC Name:
- 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: breeder Winkelmann (Kirchborchen, Germany)
- Weight at study initiation: 170-253 g
- Housing: Animals were kept in Makrolon cages type I or type III in groups of 5 animals per cage.
- Diet: standard diet (Altromin GmbH, Lage/Lippe, Germany), ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: about 24°C
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous solution with 5% cremophor
- Details on oral exposure:
- The test item was suspended in tap water with the addition of 5% cremophor and was administered to the animals in a volume of 10 mL/kg via a stomach tube.
- Doses:
- The test item was administered at dose levels of 160, 200, 250, 320, 400, 500, 630, 800, and 1000 mg/kg.
- No. of animals per sex per dose:
- 10 animals were used per dose (no data on animals per sex given).
- Control animals:
- not specified
- Details on study design:
- Toxicity symptoms and mortality rates were recorded for a 14-d observation period. Animals that died were, whenever possible, autopsied and examined for pathological changes. The surviving rats were killed at the end of the trial and also autopsied.
- Statistics:
- Computation of the LD50 values, with a confidence range of p=0.05 was carried out by means of the programmed probit analysis according to Fink and Hund [Fink H, Hund G (1965) Probitanalyse mittels programmgesteuerter Rechenanlagen. Arzneim-Forsch / Drug Res 15:624-630].
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 400 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 334 - 481
- Mortality:
- See table 1 in section "Any other information on results incl. tables".
- Clinical signs:
- other: Except for the dose of 160 mg/kg, which was symptom-free tolerated, all animals showed coordination disturbances and tonic-clonic convulsions about 1 h after administration. After 2 h, motility was reduced and the animals were temporarily laying on their
- Gross pathology:
- The autopsies did not provide any pathological findings.
- Other findings:
- no data
Any other information on results incl. tables
Table 1: Acute oral toxicty of crinipan in rats
Dose |
Number of animals used |
Toxicological result |
|
Number of animals that died |
Number of animals showing toxic symptoms |
||
160 |
10 |
0 |
0 |
200 |
10 |
1 |
10 |
250 |
10 |
2 |
10 |
320 |
10 |
5 |
10 |
400 |
10 |
5 |
10 |
500 |
10 |
7 |
10 |
630 |
10 |
6 |
10 |
800 |
10 |
9 |
10 |
1000 |
10 |
10 |
10 |
Applicant's summary and conclusion
- Interpretation of results:
- moderately toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Crinipan was found to be moderately toxic upon a single oral administration to male and female rats.
- Executive summary:
The acute toxicity of crinipan upon oral administration was studied in male and female Wistar rats (n=10 per dose). Crinipan was found to be moderately toxic, with a LD50 of 400 mg/kg.
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