Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-775-4 | CAS number: 38083-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Based on the available results, the most sensitive ErC50 value of 0.034 mg/L from the test with Lemna minor and the most sensitive ErC10 value of 0.026 mg/L from the test with Desmodesmus subspicatus (2011) were taken into account for the hazard assessment and classification.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.034 mg/L
- EC10 or NOEC for freshwater algae:
- 0.026 mg/L
Additional information
Several tests with green algae and diatoms are available. Three results are based on a recently published paper (Richter et al., 2013). Even though their reliability could not be assigned due to limited details mentioned in the publication (RL4), the results were considered in the hazard assessment and classification on the basis of a weight of evidence approach.
Two studies with Desmodesmus subspicatus are available. One study (2011, RL1) was done according to OECD 201 and GLP over 72 hours. Seven concentrations of 0.001, 0.0032, 0.01, 0.032, 0.1, 0.32 and 1 mg/L were tested in a static test. The concentrations were measured at the beginning and the end of the test. The results were based on the geometric mean of the measured concentrations. The ErC50 was determined to be 0.3 mg/L and the ErC10 to be 0.026 mg/L. The concentration not causing growth inhibition (NOEC (growth rate)) was determined to be 0.013 mg/L.
The second study with Desmodesmus subspicatus (1993, RL4) was done according to DIN EN 28692 by a laboratory of the German Federal Health Office. As only a handwritten protocol is available, a reliability could not be assigned (RL4). The protocol contains two experiments: In the first one, 8 concentrations in the range of 0.32 – 41.2 mg/L (spaced by a factor of two) and in the second experiment, 10 concentrations in the range of 0.0008 – 0.432 mg/L (spaced by a factor of two) were used.The concentration of the test substance causing 50% reduction in growth of biomass (EbC50) was determined at 0.087 mg/L. In addition, the ErC50 was determined from the raw data to be >= 0.216 mg/L (50% reduction at concentration of 0.216 mg/L and 54% reduction at concentration of 0.432 mg/L). The concentration causing 10% reduction in growth of biomass after 72h was determined to be 0.032 mg/L. The ErC10 determined from raw data was > 0.027 mg/L (3% inhibition) and < 0.054 mg/L (12.9% inhibition) after 72 hours.
Additionally to the tests with Desmodesmus subspicatus, two results based on tests with Pseudokirchneriella subcapitata and Navicula pelliculosa are available from the paper from Richter et al. (2013):
The acute toxicity of the test substance to Pseudokirchneriella subcapitata and the diatom Navicula pelliculosa was tested according to OECD 201 over 72 hours in a static system. Concentrations from 0.15 – 2.4 mg/L (P. subcapitata) and from 0.008 – 0.2 mg/L (N. pelliculosa.) were tested. The ErC50 for Pseudokirchnerialla subcapitata was determined to be 1.19 mg/L and the ErC10 to be 0.315 mg/L based on nominal concentrations. The ErC50 for Navicula pelliculosa was determined to be 0.291 mg/L and the ErC10 to be 0.108 mg/L based on nominal concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)