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Diss Factsheets
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EC number: 253-775-4 | CAS number: 38083-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Aquatic short-term toxicity
Two short term toxicity studies on fish (Danio rerio) and three studies with daphnids (Daphia magna) as well as five studies with aquatic plants (Desmodesmus subspicatus, Navicula pelliculosa and Lemna minor) are available. The results showed that fish and daphnia are clearly less sensitive than aquatic plants. The lowest LC50 (96h) with fish is 5.1 mg/L. The lowest EC50 (48h) with Daphnia magna is 10.9 mg/L.
The tests with aquatic plants show a high acute toxicity with ErC50s in the range of 0.0239 mg/L (Lemna minor) to 1.19 mg/L (Pseudokirchneriella subcapitata).The acute effects on Lemna minor were tested according to OECD 221 over 7 days. Concentrations of 0.008 – 0.2 mg/L were tested. The EC50 based on the growth rate of the frond number was determined to be 0.0239 mg/L based on mean measured concentrations. This lowest ErC50 value was used for the hazard assessment and classification.
Aquatic long-term toxicity
Four chronic tests with fish (Oryzias latipes), daphnids (Daphia magna) and aquatic plants (Desmodesmus subspicatus, Navicula pelliculosa and Lemna minor) are available.
The long term toxicity test with the substance to fish showed an EC10 (30 days) value of 0.014 mg/L.
With a NOEC of 0.2 mg/L, the daphnia are less sensitive than the fish and the most sensitive aquatic plant.
The tests with aquatic algae, diatoms and Lemna show a high chronic toxicity with ErC10s in the range of 0.026 (Desmodesmus subspicatus) to 0.0079 mg/L (Lemna minor). The lowest ErC10 of 0.0079mg/L comes from a valid study (OECD 221) with Lemna minor (2013, RL2). The results were based on the mean of the measured concentrations. The lowest ErC10 was used for the PNEC derivation and classification.
A valid respiratory inhibition study with activated sludge is also available: The EC50 was determined to be > 10000 mg/L.
Additional information
Endocrine disrupter (ED) assessment
One study was conducted in order to assess the endocrine disruptive properties of the test item - according to OECD 234 Fish Sexual Development Test (see IUCLID Section 6.1.8), in which the long term effect of the test item to fish in accordance with OECD 210 (see IUCLID Section 6.1.2) was also integrated with consideration of animal welfare. Based on the observed results, it is considered that the test item does not show any adverse endocrine effects at the concentrations tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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