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Diss Factsheets
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EC number: 264-150-0 | CAS number: 63449-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
There is adequate data to assess the irritant potential of LCCPs. In a study of liquid C20-30 LCCPs, 0.5 ml neat LCCP, which included several stabilisers, was applied as a single occlusive application for 24 hours to abraded and non-abraded skin. Erythema and oedema was scored after 24 and 72 hours. Slight erythema was observed on both the abraded and non-abraded skin in two out of six rabbits at 24 hours. In another study, up to 6 applications of 0.1ml of either liquid or solid LCCPs, either neat or in a non-irritating vehicle, were applied to the shorn back of 3 female rats on alternate 24-hour periods. It was concluded that these test materials wereas non-irritant. Single exposure to MCCPs also caused slight irritation in standard tests, but somewhat more pronounced irritation has been reported following repeated exposure, presumably due to defatting properties. In the absence of studies on repeated application of C18-20 LCCPs to skin, a conservative assumption is made that the C18-20 LCCPs could have a similar effect. There is no data on respiratory irritation of LCCPs, but this is not be anticipated to be significant exposure route.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
LCCP have been shown to be, at most, only slightly irritatating to the skin and eyes in experimental animals. Skin and eye irritation have been investigated in animal studies for a number of LCCP products. These studies suggest that LCCPs have the potential to cause slight irritation.
Single exposure to MCCPs also caused slight irritation in standard tests, but somewhat more pronounced irritation has been reported following repeated exposure, presumably due to defatting properties. The UK has advocated (UK EA, 2009) that in the absence of studies on repeated application of LCCPs to skin, a conservative assumption is made that the C18-20 LCCPs could have a similar effect.
There are no specific data on respiratory tract irritation, but on the basis of the low skin and eye irritation potential it is anticipated that the LCCP products are unlikely to cause such an effect. Further, the potential for exposure to the respiratory tract is likely to be minimal given the very low vapour pressure of LCCPs.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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