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Diss Factsheets
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EC number: 264-150-0 | CAS number: 63449-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
There is adequate data to assess the acute toxicity of LCCPs. C20-30 LCCPs (both solid and liquid) have no observed acute toxicity at top doses in the range of 5.0 to 23 g/kg bwt in several species. It is anticipated that C18-20 liquid grade LCCPs are of very low acute toxicity based on read-across to MCCPs, which have an oral LD50 >2.0 g/kg bwt in the rat.
There are no data on the acute toxicity of LCCPs following dermal administration. However, as it is anticipated that they would not be absorbed to any significant extent via this route, it is considered unnecessary to conduct such tests. Similarly, there are no data on the acute toxicity of LCCPs following inhalation, although the physico-chemical properties and the pattern of use very low vapour pressure of LCCPs make this an unlikely route of exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Valid studies in the rat, mouse, and dog have been reported on both liquid and solid LCCPs in the C20-30range. The most consistent observation made during the post-exposure period was evidence of faecal incontinence, presumably associated with the large volume of test material administered. No mortalities were observed and all studies reported LD50values > 5.0 g/kg bwt.
No valid studies have been conducted on a C18-20liquid grade LCCP. However, the fact that C14-17CPs also have high LD50values (i.e. > 2.0 g/kg bwt) suggests that this type of LCCP would have a similar low acute toxicity (UK Environment Agency, 2009).
Justification for classification or non-classification
LCCPs demonstrate a low order of acute toxicity. No mortalities were observed and the reported oral LD50values all exceeded 5,000 mg/kg bwt in the rat, mouse and dog. This conclusion is also supported by additional acute intraperitoneal (i.p.) studies in rats and mice that showed no mortality at 5,000 mg/kg bwt (i.p.) with several different LCCP test substances. The lack of acute toxicology data via inhalation or dermal exposure routes for LCCPs is not expected to be an important data gap as these routes of exposure are insignificant for LCCPs, which have very low vapour pressure and are absorbed very poorly through the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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