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Diss Factsheets
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EC number: 266-719-9 | CAS number: 67564-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
After single oral administration,14C-Fenpropimorph was rapidly absorbed from the gastrointestinal tract. Absorption was nearly complete at the high dose level and was calculated to about 90 and about 70 % at the low dose for males and females, respectively. After absorption, radioactive material was distributed in all organs and tissues. The excretion of radioactivity was rapid and occurred mainly via urine and faeces, and in the case of the morpholine-labelled-14C-Fenpropimorph, also in exhaled CO2.
The parent compound was metabolized by several hydroxylation, oxidation, sulfoxylation and demethylation process, combined with cleavage of the morpholine-ring. The decomposition product dimethylmorpholine originates from cleavage of the C-N-bondage of the parent compound. Besides, biotransformation reactions, conjugation with glucoronic acid combined with further degradations and derivative process occured.
The main biotransformation route was hydroxylation of the hydrocarbon chain, followed by a further oxidation step, associated with hydroxylation of the morpholine ring system and cleavage of the morpholine-ring-system.
Dermal absorption:
The dermal absorption of fenpropimorph was studied with concentrations of 0.04, 0.4 and 1.2 mg/cm2. For each dose level and sampling point 4 male rats were used. The exposure duration was 8 hours, after which the test substance was washed off. After 8 hours of exposure, 64 - 76% of the administered material could be washed off. The absorbed amount after 8 hours ranged between 6 - 10%, regardless of the concentration, and between 10 - 17% at 24 to 72 hours. Thus, an increase of 30 fold in the concentration resulted in no significant change of the relative absorption, indicating that the process of absorption was not saturated.
The decrease of radioactivity at the application site (from 8 to 72 hours) from 34.13 - 13.64% at 1.2 mg/cm2, from 31.10 - 8.04% at 0.40 mg/cm2and from 29.15 - 2.27 % at 0.04 mg/cm2, was not associated with a comparable increase in absorbed material. This indicates that the test substance at the site of application, after the wash, is not readily, if at all, available for dermal absorption. The report concludes that the loss was due to exfoliation. Based on the results of the in vitro study, dermal penetration through rat skin is approximately 15 times faster than through human skin, regardless of the dose level.
Based on the results available, a dermal penetration of about 10% can be assumed; which was also confirmed by EFSA in 2008 (see chapter 13).
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.